Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MICA_91MATE efflux family protein. (473 aa)    
Predicted Functional Partners:
MICA_841
Putative uncharacterized protein.
   
  
 0.766
gap
Glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
  
  
 0.741
rpsA
Ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.
  
    0.719
macB
ABC transporter family protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
  
 0.694
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.633
rplO
Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
    
   0.597
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
   
 0.554
MICA_1929
His Kinase A domain protein.
  
 
 0.543
MICA_1972
His Kinase A domain protein.
  
 
 0.522
MICA_1762
methylated-DNA-[]-cysteine S-methyltransferase family protein.
 
   
 0.494
Your Current Organism:
Micavibrio aeruginosavorus ARL13
NCBI taxonomy Id: 856793
Other names: M. aeruginosavorus ARL-13, Micavibrio aeruginosavorus ARL-13, Micavibrio aeruginosavorus str. ARL-13, Micavibrio aeruginosavorus strain ARL-13
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