| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MICA_985 | gcdH | MICA_985 | MICA_984 | Putative uncharacterized protein. | glutaryl-CoA dehydrogenase. | 0.555 |
| MICA_985 | glyA | MICA_985 | MICA_987 | Putative uncharacterized protein. | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.489 |
| MICA_985 | nrdR | MICA_985 | MICA_988 | Putative uncharacterized protein. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.415 |
| MICA_985 | rpiB | MICA_985 | MICA_986 | Putative uncharacterized protein. | Ribose 5-phosphate isomerase B. | 0.572 |
| MICA_985 | sseB | MICA_985 | MICA_983 | Putative uncharacterized protein. | Enhanced serine sensitivity protein SseB. | 0.544 |
| gcdH | MICA_985 | MICA_984 | MICA_985 | glutaryl-CoA dehydrogenase. | Putative uncharacterized protein. | 0.555 |
| gcdH | rpiB | MICA_984 | MICA_986 | glutaryl-CoA dehydrogenase. | Ribose 5-phosphate isomerase B. | 0.433 |
| gcdH | sseB | MICA_984 | MICA_983 | glutaryl-CoA dehydrogenase. | Enhanced serine sensitivity protein SseB. | 0.771 |
| glyA | MICA_985 | MICA_987 | MICA_985 | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative uncharacterized protein. | 0.489 |
| glyA | nrdR | MICA_987 | MICA_988 | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.780 |
| glyA | rpiB | MICA_987 | MICA_986 | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Ribose 5-phosphate isomerase B. | 0.972 |
| nrdR | MICA_985 | MICA_988 | MICA_985 | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Putative uncharacterized protein. | 0.415 |
| nrdR | glyA | MICA_988 | MICA_987 | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.780 |
| nrdR | rpiB | MICA_988 | MICA_986 | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Ribose 5-phosphate isomerase B. | 0.568 |
| rpiB | MICA_985 | MICA_986 | MICA_985 | Ribose 5-phosphate isomerase B. | Putative uncharacterized protein. | 0.572 |
| rpiB | gcdH | MICA_986 | MICA_984 | Ribose 5-phosphate isomerase B. | glutaryl-CoA dehydrogenase. | 0.433 |
| rpiB | glyA | MICA_986 | MICA_987 | Ribose 5-phosphate isomerase B. | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.972 |
| rpiB | nrdR | MICA_986 | MICA_988 | Ribose 5-phosphate isomerase B. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.568 |
| rpiB | sseB | MICA_986 | MICA_983 | Ribose 5-phosphate isomerase B. | Enhanced serine sensitivity protein SseB. | 0.422 |
| sseB | MICA_985 | MICA_983 | MICA_985 | Enhanced serine sensitivity protein SseB. | Putative uncharacterized protein. | 0.544 |
