| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MICA_1293 | MICA_1408 | MICA_1293 | MICA_1408 | Dihydrolipoyl dehydrogenase. | Glycine cleavage system P-family protein; Overlaps another CDS with the same product name. | 0.937 |
| MICA_1293 | MICA_1409 | MICA_1293 | MICA_1409 | Dihydrolipoyl dehydrogenase. | Glycine cleavage system P-family protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.923 |
| MICA_1293 | MICA_1804 | MICA_1293 | MICA_1804 | Dihydrolipoyl dehydrogenase. | Thymidylate synthase. | 0.903 |
| MICA_1293 | folD | MICA_1293 | MICA_1821 | Dihydrolipoyl dehydrogenase. | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.920 |
| MICA_1293 | gcvH | MICA_1293 | MICA_1411 | Dihydrolipoyl dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.975 |
| MICA_1293 | gcvT | MICA_1293 | MICA_1412 | Dihydrolipoyl dehydrogenase. | Glycine cleavage system T protein. | 0.960 |
| MICA_1293 | glyA | MICA_1293 | MICA_987 | Dihydrolipoyl dehydrogenase. | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
| MICA_1408 | MICA_1293 | MICA_1408 | MICA_1293 | Glycine cleavage system P-family protein; Overlaps another CDS with the same product name. | Dihydrolipoyl dehydrogenase. | 0.937 |
| MICA_1408 | MICA_1409 | MICA_1408 | MICA_1409 | Glycine cleavage system P-family protein; Overlaps another CDS with the same product name. | Glycine cleavage system P-family protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
| MICA_1408 | MICA_1804 | MICA_1408 | MICA_1804 | Glycine cleavage system P-family protein; Overlaps another CDS with the same product name. | Thymidylate synthase. | 0.908 |
| MICA_1408 | folD | MICA_1408 | MICA_1821 | Glycine cleavage system P-family protein; Overlaps another CDS with the same product name. | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.968 |
| MICA_1408 | gcvH | MICA_1408 | MICA_1411 | Glycine cleavage system P-family protein; Overlaps another CDS with the same product name. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
| MICA_1408 | gcvT | MICA_1408 | MICA_1412 | Glycine cleavage system P-family protein; Overlaps another CDS with the same product name. | Glycine cleavage system T protein. | 0.999 |
| MICA_1408 | glyA | MICA_1408 | MICA_987 | Glycine cleavage system P-family protein; Overlaps another CDS with the same product name. | Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.985 |
| MICA_1409 | MICA_1293 | MICA_1409 | MICA_1293 | Glycine cleavage system P-family protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Dihydrolipoyl dehydrogenase. | 0.923 |
| MICA_1409 | MICA_1408 | MICA_1409 | MICA_1408 | Glycine cleavage system P-family protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Glycine cleavage system P-family protein; Overlaps another CDS with the same product name. | 0.999 |
| MICA_1409 | MICA_1804 | MICA_1409 | MICA_1804 | Glycine cleavage system P-family protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Thymidylate synthase. | 0.905 |
| MICA_1409 | folD | MICA_1409 | MICA_1821 | Glycine cleavage system P-family protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.928 |
| MICA_1409 | gcvH | MICA_1409 | MICA_1411 | Glycine cleavage system P-family protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
| MICA_1409 | gcvT | MICA_1409 | MICA_1412 | Glycine cleavage system P-family protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Glycine cleavage system T protein. | 0.999 |
