node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDO48732.1 | clpA | BM1374166_01049 | BM1374166_00845 | Hypothetical protein. | Endopeptidase Clp ATP-binding chain A; Belongs to the ClpA/ClpB family. | 0.775 |
CDO48732.1 | clpB | BM1374166_01049 | BM1374166_01847 | Hypothetical protein. | ATP-dependent clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.775 |
CDO48732.1 | clpP | BM1374166_01049 | BM1374166_00815 | Hypothetical protein. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.514 |
CDO48732.1 | dnaK | BM1374166_01049 | BM1374166_00060 | Hypothetical protein. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.954 |
CDO48732.1 | groEL | BM1374166_01049 | BM1374166_01963 | Hypothetical protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.800 |
CDO48732.1 | grpE | BM1374166_01049 | BM1374166_00051 | Hypothetical protein. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.825 |
CDO48732.1 | hrcA | BM1374166_01049 | BM1374166_00050 | Hypothetical protein. | Heat-inducible transcription repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.642 |
clpA | CDO48732.1 | BM1374166_00845 | BM1374166_01049 | Endopeptidase Clp ATP-binding chain A; Belongs to the ClpA/ClpB family. | Hypothetical protein. | 0.775 |
clpA | clpP | BM1374166_00845 | BM1374166_00815 | Endopeptidase Clp ATP-binding chain A; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.914 |
clpA | dnaJ | BM1374166_00845 | BM1374166_00061 | Endopeptidase Clp ATP-binding chain A; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.777 |
clpA | dnaJ1 | BM1374166_00845 | BM1374166_00601 | Endopeptidase Clp ATP-binding chain A; Belongs to the ClpA/ClpB family. | Heat shock protein DnaJ. | 0.800 |
clpA | dnaJ2 | BM1374166_00845 | BM1374166_02209 | Endopeptidase Clp ATP-binding chain A; Belongs to the ClpA/ClpB family. | Heat shock protein DnaJ. | 0.773 |
clpA | dnaK | BM1374166_00845 | BM1374166_00060 | Endopeptidase Clp ATP-binding chain A; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.933 |
clpA | groEL | BM1374166_00845 | BM1374166_01963 | Endopeptidase Clp ATP-binding chain A; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.708 |
clpA | grpE | BM1374166_00845 | BM1374166_00051 | Endopeptidase Clp ATP-binding chain A; Belongs to the ClpA/ClpB family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.796 |
clpA | hrcA | BM1374166_00845 | BM1374166_00050 | Endopeptidase Clp ATP-binding chain A; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.651 |
clpB | CDO48732.1 | BM1374166_01847 | BM1374166_01049 | ATP-dependent clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Hypothetical protein. | 0.775 |
clpB | clpP | BM1374166_01847 | BM1374166_00815 | ATP-dependent clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.908 |
clpB | dnaJ | BM1374166_01847 | BM1374166_00061 | ATP-dependent clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.779 |
clpB | dnaJ1 | BM1374166_01847 | BM1374166_00601 | ATP-dependent clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein DnaJ. | 0.801 |