ARO1 protein (Nadsonia fulvescens) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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ARO1

3-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the 2nd section; belongs to the EPSP synthase family. In the 4th section; belongs to the type-I 3-dehydroquinase family. In the N-terminal section; belongs to the dehydroquinate synthase family. (1567 aa)

Predicted Functional Partners:

A0A1E3PHT0

0.982

A0A1E3PJL1

0.943

A0A1E3PPZ4

0.935

A0A1E3PN90

0.917

A0A1E3PFT2

0.911

A0A1E3PH74

0.902

A0A1E3PND2

0.880

A0A1E3PIC7

0.873

A0A1E3PE16

0.872

A0A1E3PSP7

0.869

Your Current Organism:

Nadsonia fulvescens

NCBI taxonomy Id: 857566
Other names: N. fulvescens var. elongata DSM 6958, Nadsonia fulvescens var. elongata DSM 6958

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1E3PE16	A0A1E3PFT2	A0A1E3PE16	A0A1E3PFT2	Tryptophan synthase.	PDT-domain-containing protein.	0.819
A0A1E3PE16	A0A1E3PH74	A0A1E3PE16	A0A1E3PH74	Tryptophan synthase.	Histidinol-phosphate aminotransferase.	0.986
A0A1E3PE16	A0A1E3PHT0	A0A1E3PE16	A0A1E3PHT0	Tryptophan synthase.	IGPS-domain-containing protein.	0.999
A0A1E3PE16	A0A1E3PJL1	A0A1E3PE16	A0A1E3PJL1	Tryptophan synthase.	Chorismate synthase.	0.984
A0A1E3PE16	A0A1E3PN90	A0A1E3PE16	A0A1E3PN90	Tryptophan synthase.	Histidine biosynthesis trifunctional protein.	0.987
A0A1E3PE16	A0A1E3PND2	A0A1E3PE16	A0A1E3PND2	Tryptophan synthase.	Anthranilate synthase component.	0.994
A0A1E3PE16	A0A1E3PPZ4	A0A1E3PE16	A0A1E3PPZ4	Tryptophan synthase.	Chorismate mutase.	0.811
A0A1E3PE16	ARO1	A0A1E3PE16	A0A1E3PQF0	Tryptophan synthase.	3-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the 2nd section; belongs to the EPSP synthase family. In the 4th section; belongs to the type-I 3-dehydroquinase family. In the N-terminal section; belongs to the dehydroquinate synthase family.	0.872
A0A1E3PFT2	A0A1E3PE16	A0A1E3PFT2	A0A1E3PE16	PDT-domain-containing protein.	Tryptophan synthase.	0.819
A0A1E3PFT2	A0A1E3PH74	A0A1E3PFT2	A0A1E3PH74	PDT-domain-containing protein.	Histidinol-phosphate aminotransferase.	0.915
A0A1E3PFT2	A0A1E3PHT0	A0A1E3PFT2	A0A1E3PHT0	PDT-domain-containing protein.	IGPS-domain-containing protein.	0.961
A0A1E3PFT2	A0A1E3PIC7	A0A1E3PFT2	A0A1E3PIC7	PDT-domain-containing protein.	Phospho-2-dehydro-3-deoxyheptonate aldolase.	0.413
A0A1E3PFT2	A0A1E3PJL1	A0A1E3PFT2	A0A1E3PJL1	PDT-domain-containing protein.	Chorismate synthase.	0.913
A0A1E3PFT2	A0A1E3PN90	A0A1E3PFT2	A0A1E3PN90	PDT-domain-containing protein.	Histidine biosynthesis trifunctional protein.	0.632
A0A1E3PFT2	A0A1E3PND2	A0A1E3PFT2	A0A1E3PND2	PDT-domain-containing protein.	Anthranilate synthase component.	0.804
A0A1E3PFT2	A0A1E3PPZ4	A0A1E3PFT2	A0A1E3PPZ4	PDT-domain-containing protein.	Chorismate mutase.	0.958
A0A1E3PFT2	A0A1E3PSP7	A0A1E3PFT2	A0A1E3PSP7	PDT-domain-containing protein.	Phospho-2-dehydro-3-deoxyheptonate aldolase.	0.464
A0A1E3PFT2	ARO1	A0A1E3PFT2	A0A1E3PQF0	PDT-domain-containing protein.	3-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the 2nd section; belongs to the EPSP synthase family. In the 4th section; belongs to the type-I 3-dehydroquinase family. In the N-terminal section; belongs to the dehydroquinate synthase family.	0.911
A0A1E3PH74	A0A1E3PE16	A0A1E3PH74	A0A1E3PE16	Histidinol-phosphate aminotransferase.	Tryptophan synthase.	0.986
A0A1E3PH74	A0A1E3PFT2	A0A1E3PH74	A0A1E3PFT2	Histidinol-phosphate aminotransferase.	PDT-domain-containing protein.	0.915

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Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.934

expected number of edges:

35

PPI enrichment p-value:

0.0106

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

6 of 207

1.19

1.14

0.00026

GO:0018106

Peptidyl-histidine phosphorylation

4 of 104

1.31

0.98

0.0037

GO:0050794

Regulation of cellular process

9 of 641

0.87

0.8

0.00013

GO:0050896

Response to stimulus

7 of 541

0.84

0.66

0.0019

GO:0006796

Phosphate-containing compound metabolic process

5 of 376

0.85

0.5

0.0311

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

5 of 109

1.39

1.23

0.00077

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3523

Mixed, incl. PAS-associated, C-terminal, and AAA ATPase domain

6 of 19

2.23

4.45

3.73e-10

CL:3520

PAS-associated, C-terminal, and GGDEF domain

7 of 30

2.1

4.44

8.77e-11

CL:3526

PAS-associated, C-terminal, and AAA ATPase domain

4 of 13

2.22

2.89

1.72e-06

CL:3527

PAS-associated, C-terminal, and AAA ATPase domain

3 of 7

2.36

2.23

5.66e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 575

0.92

0.96

4.76e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

5 of 110

1.39

1.43

0.00012

KW-0418

Kinase

6 of 161

1.3

1.42

4.12e-05

KW-0902

Two-component regulatory system

3 of 48

1.52

1.0

0.0067

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

6 of 72

1.65

2.17

3.67e-06

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

5 of 50

1.73

2.13

1.03e-05

IPR005467

Histidine kinase domain

6 of 80

1.6

2.1

3.67e-06

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

5 of 56

1.68

2.03

1.39e-05

IPR003594

Histidine kinase/HSP90-like ATPase

6 of 96

1.52

1.92

6.30e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

5 of 56

1.68

2.21

3.75e-06

SM00387

Histidine kinase-like ATPases

6 of 104

1.49

1.95

2.68e-06

SM00448

cheY-homologous receiver domain

5 of 101

1.42

1.59

4.10e-05

SM00073

Histidine Phosphotransfer domain

2 of 10

2.03

1.08

0.0087

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

2 of 18

1.77

0.87

0.0199

(more ...)

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