STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDB23286.1Replication initiator protein A. (579 aa)    
Predicted Functional Partners:
SDB23272.1
Ribosome-associated protein.
       0.601
GyrB
DNA gyrase subunit B.
       0.545
SDB23240.1
Protein of unknown function.
       0.545
SDB23254.1
DNA replication and repair protein RecF.
       0.545
SDB23194.1
Hypothetical protein.
       0.434
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
       0.434
SDB23177.1
phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family.
       0.415
Your Current Organism:
Fusobacterium necrophorum
NCBI taxonomy Id: 859
Other names: ATCC 25286, Acinomyces pseudonecrophorus, Actinomyces necrophorus, Bacillus necrophorus, Bacillus necroseos, Bacillus necrosus, Bacterium necrophorum, Bacteroides necrophorus, CCUG 9994, CIP 104559, Corynebacterium necrophorum, DSM 21784, F. necrophorum, Fusibacterium necrophorum, Fusiformis hemolyticus, Fusiformis necrophorus, JCM 3718, NCTC 13726, Necrobacterium necrophorus, Proactinomyces necrophorus, Sphaerophorus necrophorus, Sphaerophorus pseudonecrophorus, Streptothrix necrophorus, Streptothrix necuphtora, VPI 2891
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