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cai protein (Helicobacter pylori 26695) - STRING interaction network
"cai" - Cytotoxicity-associated immunodominant antigen in Helicobacter pylori 26695
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
caiCytotoxicity-associated immunodominant antigen; May be necessary for the transcription, folding, export, or function of the cytotoxin (1186 aa)    
Predicted Functional Partners:
glmM
Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family (445 aa)
     
   
  0.863
cagE
CAG pathogenicity island protein 23; Involved in DNA transfer. Required for induction of IL-8 in gastric epithelial cells (983 aa)
         
  0.862
cagT
annotation not available (223 aa)
           
  0.859
ureA
Urease subunit alpha; Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach; In the N-terminal section; belongs to the urease gamma subunit family (238 aa)
           
  0.859
tpx
Thiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily (166 aa)
           
  0.839
ureB
Urease subunit beta; Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family (569 aa)
           
  0.833
flaA
Flagellin A; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Important for motility and virulence (510 aa)
       
 
  0.823
hpaA
annotation not available (260 aa)
           
  0.819
dps
DNA protection during starvation protein; Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role in the accumulation of neutrophil [...] (144 aa)
           
  0.813
groEL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (546 aa)
     
   
  0.794
Your Current Organism:
Helicobacter pylori 26695
NCBI taxonomy Id: 85962
Other names: H. pylori 26695, Helicobacter pylori (strain 26695), Helicobacter pylori 26695, Helicobacter pylori ATCC 700392, Helicobacter pylori KE26695, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695
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