node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HP_0236 | HP_0240 | HP_0236 | HP_0240 | Predicted coding region HP0236; Hypothetical protein; identified by GeneMark; putative. | Octaprenyl-diphosphate synthase (ispB); Similar to SP:P19641 GB:X68873 PID:388220 PID:606125 GB:U00096 percent identity: 31.62; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. | 0.768 |
HP_0236 | HP_0241 | HP_0236 | HP_0241 | Predicted coding region HP0236; Hypothetical protein; identified by GeneMark; putative. | Predicted coding region HP0241; Hypothetical protein; identified by GeneMark; putative. | 0.767 |
HP_0236 | HP_0242 | HP_0236 | HP_0242 | Predicted coding region HP0236; Hypothetical protein; identified by GeneMark; putative. | Predicted coding region HP0242; Hypothetical protein; identified by GeneMark; putative. | 0.767 |
HP_0236 | HP_0245 | HP_0236 | HP_0245 | Predicted coding region HP0236; Hypothetical protein; identified by GeneMark; putative. | Predicted coding region HP0245; Hypothetical protein; identified by GeneMark; putative; To C.jejuni CJ1463. | 0.413 |
HP_0236 | dps | HP_0236 | HP_0243 | Predicted coding region HP0236; Hypothetical protein; identified by GeneMark; putative. | Neutrophil activating protein (napA) (bacterioferritin); Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role in the accumulatio [...] | 0.713 |
HP_0236 | flgS | HP_0236 | HP_0244 | Predicted coding region HP0236; Hypothetical protein; identified by GeneMark; putative. | Signal-transducing protein, histidine kinase (atoS); Member of the two-component regulatory system FlgR/FlgS that induces the transcriptional induction of the genes needed in motility and flagellar biogenesis. Plays also an essential role in bacterial survival at pH 2.5 independently of FlgR. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of FlgR. In turn, FlgR functions as a transcriptional regulator initiating transcription from RpoN- dependent pr [...] | 0.413 |
HP_0236 | hcpE | HP_0236 | HP_0235 | Predicted coding region HP0236; Hypothetical protein; identified by GeneMark; putative. | Conserved hypothetical secreted protein; May hydrolyze 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives; Belongs to the hcp beta-lactamase family. | 0.539 |
HP_0236 | hemA | HP_0236 | HP_0239 | Predicted coding region HP0236; Hypothetical protein; identified by GeneMark; putative. | glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.768 |
HP_0236 | hemC | HP_0236 | HP_0237 | Predicted coding region HP0236; Hypothetical protein; identified by GeneMark; putative. | Porphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.774 |
HP_0236 | proS | HP_0236 | HP_0238 | Predicted coding region HP0236; Hypothetical protein; identified by GeneMark; putative. | prolyl-tRNA synthetase (proS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and invol [...] | 0.768 |
HP_0240 | HP_0236 | HP_0240 | HP_0236 | Octaprenyl-diphosphate synthase (ispB); Similar to SP:P19641 GB:X68873 PID:388220 PID:606125 GB:U00096 percent identity: 31.62; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. | Predicted coding region HP0236; Hypothetical protein; identified by GeneMark; putative. | 0.768 |
HP_0240 | HP_0241 | HP_0240 | HP_0241 | Octaprenyl-diphosphate synthase (ispB); Similar to SP:P19641 GB:X68873 PID:388220 PID:606125 GB:U00096 percent identity: 31.62; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. | Predicted coding region HP0241; Hypothetical protein; identified by GeneMark; putative. | 0.774 |
HP_0240 | HP_0242 | HP_0240 | HP_0242 | Octaprenyl-diphosphate synthase (ispB); Similar to SP:P19641 GB:X68873 PID:388220 PID:606125 GB:U00096 percent identity: 31.62; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. | Predicted coding region HP0242; Hypothetical protein; identified by GeneMark; putative. | 0.837 |
HP_0240 | HP_0245 | HP_0240 | HP_0245 | Octaprenyl-diphosphate synthase (ispB); Similar to SP:P19641 GB:X68873 PID:388220 PID:606125 GB:U00096 percent identity: 31.62; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. | Predicted coding region HP0245; Hypothetical protein; identified by GeneMark; putative; To C.jejuni CJ1463. | 0.438 |
HP_0240 | dps | HP_0240 | HP_0243 | Octaprenyl-diphosphate synthase (ispB); Similar to SP:P19641 GB:X68873 PID:388220 PID:606125 GB:U00096 percent identity: 31.62; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. | Neutrophil activating protein (napA) (bacterioferritin); Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role in the accumulatio [...] | 0.798 |
HP_0240 | flgS | HP_0240 | HP_0244 | Octaprenyl-diphosphate synthase (ispB); Similar to SP:P19641 GB:X68873 PID:388220 PID:606125 GB:U00096 percent identity: 31.62; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. | Signal-transducing protein, histidine kinase (atoS); Member of the two-component regulatory system FlgR/FlgS that induces the transcriptional induction of the genes needed in motility and flagellar biogenesis. Plays also an essential role in bacterial survival at pH 2.5 independently of FlgR. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of FlgR. In turn, FlgR functions as a transcriptional regulator initiating transcription from RpoN- dependent pr [...] | 0.428 |
HP_0240 | hcpE | HP_0240 | HP_0235 | Octaprenyl-diphosphate synthase (ispB); Similar to SP:P19641 GB:X68873 PID:388220 PID:606125 GB:U00096 percent identity: 31.62; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. | Conserved hypothetical secreted protein; May hydrolyze 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives; Belongs to the hcp beta-lactamase family. | 0.534 |
HP_0240 | hemA | HP_0240 | HP_0239 | Octaprenyl-diphosphate synthase (ispB); Similar to SP:P19641 GB:X68873 PID:388220 PID:606125 GB:U00096 percent identity: 31.62; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. | glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.837 |
HP_0240 | hemC | HP_0240 | HP_0237 | Octaprenyl-diphosphate synthase (ispB); Similar to SP:P19641 GB:X68873 PID:388220 PID:606125 GB:U00096 percent identity: 31.62; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. | Porphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.890 |
HP_0240 | proS | HP_0240 | HP_0238 | Octaprenyl-diphosphate synthase (ispB); Similar to SP:P19641 GB:X68873 PID:388220 PID:606125 GB:U00096 percent identity: 31.62; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. | prolyl-tRNA synthetase (proS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and invol [...] | 0.837 |