STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HP_0242Predicted coding region HP0242; Hypothetical protein; identified by GeneMark; putative. (94 aa)    
Predicted Functional Partners:
hemA
glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
    0.837
HP_0240
Octaprenyl-diphosphate synthase (ispB); Similar to SP:P19641 GB:X68873 PID:388220 PID:606125 GB:U00096 percent identity: 31.62; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family.
  
    0.837
proS
prolyl-tRNA synthetase (proS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and invol [...]
       0.836
hemC
Porphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
    0.829
dps
Neutrophil activating protein (napA) (bacterioferritin); Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role in the accumulatio [...]
  
    0.798
HP_0241
Predicted coding region HP0241; Hypothetical protein; identified by GeneMark; putative.
  
    0.776
HP_0236
Predicted coding region HP0236; Hypothetical protein; identified by GeneMark; putative.
       0.767
hcpE
Conserved hypothetical secreted protein; May hydrolyze 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives; Belongs to the hcp beta-lactamase family.
       0.534
HP_0245
Predicted coding region HP0245; Hypothetical protein; identified by GeneMark; putative; To C.jejuni CJ1463.
       0.434
flgS
Signal-transducing protein, histidine kinase (atoS); Member of the two-component regulatory system FlgR/FlgS that induces the transcriptional induction of the genes needed in motility and flagellar biogenesis. Plays also an essential role in bacterial survival at pH 2.5 independently of FlgR. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of FlgR. In turn, FlgR functions as a transcriptional regulator initiating transcription from RpoN- dependent pr [...]
       0.415
Your Current Organism:
Helicobacter pylori
NCBI taxonomy Id: 85962
Other names: H. pylori 26695, Helicobacter pylori (strain 26695), Helicobacter pylori 26695, Helicobacter pylori ATCC 700392, Helicobacter pylori KE26695, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695
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