node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HP_0841 | coaD | HP_0841 | HP_1475 | Pantothenate metabolism flavoprotein (dfp); Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Lipopolysaccharide core biosynthesis protein (kdtB); Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. | 0.956 |
HP_0841 | coaX | HP_0841 | HP_0862 | Pantothenate metabolism flavoprotein (dfp); Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Predicted coding region HP0862; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Can also utilize CTP or GTP instead of ATP as a phosphoryl donor, albeit to a lesser extent. | 0.935 |
HP_0841 | panC | HP_0841 | HP_0006 | Pantothenate metabolism flavoprotein (dfp); Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantoate-beta-alanine ligase (panC); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.953 |
HP_0859 | HP_0861 | HP_0859 | HP_0861 | ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD); Similar to SP:P37420 GB:U06472 GB:X52093 PID:459160 percent identity: 32.73; identified by sequence similarity; putative. | Predicted coding region HP0861; Hypothetical protein; identified by GeneMark; putative. | 0.853 |
HP_0859 | HP_0864 | HP_0859 | HP_0864 | ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD); Similar to SP:P37420 GB:U06472 GB:X52093 PID:459160 percent identity: 32.73; identified by sequence similarity; putative. | Predicted coding region HP0864; Hypothetical protein; identified by GeneMark; putative. | 0.837 |
HP_0859 | coaX | HP_0859 | HP_0862 | ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD); Similar to SP:P37420 GB:U06472 GB:X52093 PID:459160 percent identity: 32.73; identified by sequence similarity; putative. | Predicted coding region HP0862; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Can also utilize CTP or GTP instead of ATP as a phosphoryl donor, albeit to a lesser extent. | 0.837 |
HP_0859 | gmhB | HP_0859 | HP_0860 | ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD); Similar to SP:P37420 GB:U06472 GB:X52093 PID:459160 percent identity: 32.73; identified by sequence similarity; putative. | Conserved hypothetical protein; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position; Belongs to the GmhB family. | 0.933 |
HP_0859 | greA | HP_0859 | HP_0866 | ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD); Similar to SP:P37420 GB:U06472 GB:X52093 PID:459160 percent identity: 32.73; identified by sequence similarity; putative. | Transcription elongation factor GreA (greA); Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. | 0.837 |
HP_0859 | hldE | HP_0859 | HP_0858 | ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD); Similar to SP:P37420 GB:U06472 GB:X52093 PID:459160 percent identity: 32.73; identified by sequence similarity; putative. | ADP-heptose synthase (rfaE); Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.997 |
HP_0859 | pgbB | HP_0859 | HP_0863 | ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD); Similar to SP:P37420 GB:U06472 GB:X52093 PID:459160 percent identity: 32.73; identified by sequence similarity; putative. | Predicted coding region HP0863; Binds plasminogen, specifically, and in a concentration and lysine-dependent manner. Plasminogen is the precursor of plasmin, a serine protease that cleaves fibrin, fibronectin, laminin and vitronectin. Acquisition of plasminogen/plasmin could enable H.pylori to degrade host components. | 0.837 |
HP_0861 | HP_0859 | HP_0861 | HP_0859 | Predicted coding region HP0861; Hypothetical protein; identified by GeneMark; putative. | ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD); Similar to SP:P37420 GB:U06472 GB:X52093 PID:459160 percent identity: 32.73; identified by sequence similarity; putative. | 0.853 |
HP_0861 | HP_0864 | HP_0861 | HP_0864 | Predicted coding region HP0861; Hypothetical protein; identified by GeneMark; putative. | Predicted coding region HP0864; Hypothetical protein; identified by GeneMark; putative. | 0.837 |
HP_0861 | coaX | HP_0861 | HP_0862 | Predicted coding region HP0861; Hypothetical protein; identified by GeneMark; putative. | Predicted coding region HP0862; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Can also utilize CTP or GTP instead of ATP as a phosphoryl donor, albeit to a lesser extent. | 0.873 |
HP_0861 | gmhB | HP_0861 | HP_0860 | Predicted coding region HP0861; Hypothetical protein; identified by GeneMark; putative. | Conserved hypothetical protein; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position; Belongs to the GmhB family. | 0.838 |
HP_0861 | greA | HP_0861 | HP_0866 | Predicted coding region HP0861; Hypothetical protein; identified by GeneMark; putative. | Transcription elongation factor GreA (greA); Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. | 0.837 |
HP_0861 | hldE | HP_0861 | HP_0858 | Predicted coding region HP0861; Hypothetical protein; identified by GeneMark; putative. | ADP-heptose synthase (rfaE); Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.866 |
HP_0861 | pgbB | HP_0861 | HP_0863 | Predicted coding region HP0861; Hypothetical protein; identified by GeneMark; putative. | Predicted coding region HP0863; Binds plasminogen, specifically, and in a concentration and lysine-dependent manner. Plasminogen is the precursor of plasmin, a serine protease that cleaves fibrin, fibronectin, laminin and vitronectin. Acquisition of plasminogen/plasmin could enable H.pylori to degrade host components. | 0.837 |
HP_0864 | HP_0859 | HP_0864 | HP_0859 | Predicted coding region HP0864; Hypothetical protein; identified by GeneMark; putative. | ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD); Similar to SP:P37420 GB:U06472 GB:X52093 PID:459160 percent identity: 32.73; identified by sequence similarity; putative. | 0.837 |
HP_0864 | HP_0861 | HP_0864 | HP_0861 | Predicted coding region HP0864; Hypothetical protein; identified by GeneMark; putative. | Predicted coding region HP0861; Hypothetical protein; identified by GeneMark; putative. | 0.837 |
HP_0864 | coaX | HP_0864 | HP_0862 | Predicted coding region HP0864; Hypothetical protein; identified by GeneMark; putative. | Predicted coding region HP0862; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. Can also utilize CTP or GTP instead of ATP as a phosphoryl donor, albeit to a lesser extent. | 0.837 |