Urease accessory protein (ureF); Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.

Urease accessory protein (ureE); Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

Urease beta subunit (urea amidohydrolase) (ureB); Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.

Urease alpha subunit (ureA) (urea amidohydrolase); Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach; In the N-terminal section; belongs to the urease gamma subunit family.

Urease accessory protein (ureI); Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for the adaptation of urease activity to the extracellular pH, as in the presence of urea, UreI rapidly enhances the production of ammonia in the extracellular medium when the pH of the medium was decreased to pH5 or below.

Urease protein (ureC); Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.

Hydrogenase expression/formation protein (hypA); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Is also required for urease maturation.

Peptidyl-prolyl cis-trans isomerase, FKBP-type rotamase (slyD); Folding helper with both chaperone and peptidyl-prolyl cis- trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa- Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction (By similarity); Bel [...]

Hydrogenase expression/formation protein (hypC); Similar to GB:L77117 SP:Q57653 PID:1498975 percent identity: 38.46; identified by sequence similarity; putative.