| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HP_0033 | HP_1024 | HP_0033 | HP_1024 | ATP-dependent C1p protease (clpA); Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 40.46; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | Co-chaperone-curved DNA binding protein A (CbpA); Similar to GB:L42023 SP:P43735 PID:1007148 PID:1221366 PID:1205479 percent identity: 37.68; identified by sequence similarity; putative. | 0.667 |
| HP_0033 | dnaJ | HP_0033 | HP_1332 | ATP-dependent C1p protease (clpA); Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 40.46; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | Co-chaperone and heat shock protein (dnaJ); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interact [...] | 0.766 |
| HP_0033 | dnaK | HP_0033 | HP_0109 | ATP-dependent C1p protease (clpA); Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 40.46; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | Chaperone and heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.962 |
| HP_0033 | groL | HP_0033 | HP_0010 | ATP-dependent C1p protease (clpA); Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 40.46; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | Chaperone and heat shock protein (groEL); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.549 |
| HP_0033 | groS | HP_0033 | HP_0011 | ATP-dependent C1p protease (clpA); Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 40.46; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | Co-chaperone (groES); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | 0.612 |
| HP_0033 | grpE | HP_0033 | HP_0110 | ATP-dependent C1p protease (clpA); Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 40.46; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | Co-chaperone and heat shock protein (grpE); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sev [...] | 0.820 |
| HP_0033 | htpG | HP_0033 | HP_0210 | ATP-dependent C1p protease (clpA); Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 40.46; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | Chaperone and heat shock protein C62.5 (htpG); Molecular chaperone. Has ATPase activity. | 0.800 |
| HP_0221 | dnaK | HP_0221 | HP_0109 | nifU-like protein; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. | Chaperone and heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.965 |
| HP_0221 | groL | HP_0221 | HP_0010 | nifU-like protein; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. | Chaperone and heat shock protein (groEL); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.533 |
| HP_0221 | groS | HP_0221 | HP_0011 | nifU-like protein; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. | Co-chaperone (groES); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | 0.588 |
| HP_0221 | grpE | HP_0221 | HP_0110 | nifU-like protein; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. | Co-chaperone and heat shock protein (grpE); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sev [...] | 0.479 |
| HP_0221 | htpG | HP_0221 | HP_0210 | nifU-like protein; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. | Chaperone and heat shock protein C62.5 (htpG); Molecular chaperone. Has ATPase activity. | 0.405 |
| HP_1024 | HP_0033 | HP_1024 | HP_0033 | Co-chaperone-curved DNA binding protein A (CbpA); Similar to GB:L42023 SP:P43735 PID:1007148 PID:1221366 PID:1205479 percent identity: 37.68; identified by sequence similarity; putative. | ATP-dependent C1p protease (clpA); Similar to GB:M31045 SP:P15716 PID:145549 PID:499142 GB:U00096 percent identity: 40.46; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | 0.667 |
| HP_1024 | clpB | HP_1024 | HP_0264 | Co-chaperone-curved DNA binding protein A (CbpA); Similar to GB:L42023 SP:P43735 PID:1007148 PID:1221366 PID:1205479 percent identity: 37.68; identified by sequence similarity; putative. | ATP-dependent protease binding subunit (clpB); Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Necessary for sur [...] | 0.667 |
| HP_1024 | dnaK | HP_1024 | HP_0109 | Co-chaperone-curved DNA binding protein A (CbpA); Similar to GB:L42023 SP:P43735 PID:1007148 PID:1221366 PID:1205479 percent identity: 37.68; identified by sequence similarity; putative. | Chaperone and heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.994 |
| HP_1024 | groL | HP_1024 | HP_0010 | Co-chaperone-curved DNA binding protein A (CbpA); Similar to GB:L42023 SP:P43735 PID:1007148 PID:1221366 PID:1205479 percent identity: 37.68; identified by sequence similarity; putative. | Chaperone and heat shock protein (groEL); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.872 |
| HP_1024 | groS | HP_1024 | HP_0011 | Co-chaperone-curved DNA binding protein A (CbpA); Similar to GB:L42023 SP:P43735 PID:1007148 PID:1221366 PID:1205479 percent identity: 37.68; identified by sequence similarity; putative. | Co-chaperone (groES); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | 0.755 |
| HP_1024 | grpE | HP_1024 | HP_0110 | Co-chaperone-curved DNA binding protein A (CbpA); Similar to GB:L42023 SP:P43735 PID:1007148 PID:1221366 PID:1205479 percent identity: 37.68; identified by sequence similarity; putative. | Co-chaperone and heat shock protein (grpE); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sev [...] | 0.968 |
| HP_1024 | hrcA | HP_1024 | HP_0111 | Co-chaperone-curved DNA binding protein A (CbpA); Similar to GB:L42023 SP:P43735 PID:1007148 PID:1221366 PID:1205479 percent identity: 37.68; identified by sequence similarity; putative. | Predicted coding region HP0111; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.773 |
| HP_1024 | htpG | HP_1024 | HP_0210 | Co-chaperone-curved DNA binding protein A (CbpA); Similar to GB:L42023 SP:P43735 PID:1007148 PID:1221366 PID:1205479 percent identity: 37.68; identified by sequence similarity; putative. | Chaperone and heat shock protein C62.5 (htpG); Molecular chaperone. Has ATPase activity. | 0.920 |
