Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HP_0162 | arsR | HP_0162 | HP_0166 | Conserved hypothetical protein; Similar to PID:1183839 percent identity: 36.65; identified by sequence similarity; putative. | Response regulator (ompR); Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways. Upon phosphorylation by ArsS, functions as a transcription regulator by direct binding to promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH. Negatively autoregulates its expression. | 0.713 |
| HP_0162 | arsS | HP_0162 | HP_0164 | Conserved hypothetical protein; Similar to PID:1183839 percent identity: 36.65; identified by sequence similarity; putative. | Signal-transducing protein, histidine kinase; Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of ArsR. In turn, ArsR binds to the upstream promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH. Participates [...] | 0.684 |
| HP_0162 | hemB | HP_0162 | HP_0163 | Conserved hypothetical protein; Similar to PID:1183839 percent identity: 36.65; identified by sequence similarity; putative. | Delta-aminolevulinic acid dehydratase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.879 |
| HP_0598 | hemB | HP_0598 | HP_0163 | 8-amino-7-oxononanoate synthase (bioF); Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Delta-aminolevulinic acid dehydratase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.646 |
| HP_0598 | hemE | HP_0598 | HP_0604 | 8-amino-7-oxononanoate synthase (bioF); Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Uroporphyrinogen decarboxylase (hemE); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.496 |
| HP_0598 | hemL | HP_0598 | HP_0306 | 8-amino-7-oxononanoate synthase (bioF); Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Glutamate-1-semialdehyde 2,1-aminomutase (hemL); Similar to GB:D26562 SP:P23893 GB:X53696 PID:41621 PID:473813 percent identity: 51.30; identified by sequence similarity; putative. | 0.478 |
| HP_1224 | hemA | HP_1224 | HP_0239 | Uroporphyrinogen III cosynthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.624 |
| HP_1224 | hemB | HP_1224 | HP_0163 | Uroporphyrinogen III cosynthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Delta-aminolevulinic acid dehydratase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.929 |
| HP_1224 | hemC | HP_1224 | HP_0237 | Uroporphyrinogen III cosynthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
| HP_1224 | hemE | HP_1224 | HP_0604 | Uroporphyrinogen III cosynthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase (hemE); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.953 |
| HP_1224 | hemL | HP_1224 | HP_0306 | Uroporphyrinogen III cosynthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde 2,1-aminomutase (hemL); Similar to GB:D26562 SP:P23893 GB:X53696 PID:41621 PID:473813 percent identity: 51.30; identified by sequence similarity; putative. | 0.660 |
| arsR | HP_0162 | HP_0166 | HP_0162 | Response regulator (ompR); Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways. Upon phosphorylation by ArsS, functions as a transcription regulator by direct binding to promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH. Negatively autoregulates its expression. | Conserved hypothetical protein; Similar to PID:1183839 percent identity: 36.65; identified by sequence similarity; putative. | 0.713 |
| arsR | arsS | HP_0166 | HP_0164 | Response regulator (ompR); Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways. Upon phosphorylation by ArsS, functions as a transcription regulator by direct binding to promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH. Negatively autoregulates its expression. | Signal-transducing protein, histidine kinase; Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of ArsR. In turn, ArsR binds to the upstream promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH. Participates [...] | 0.981 |
| arsR | hemB | HP_0166 | HP_0163 | Response regulator (ompR); Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways. Upon phosphorylation by ArsS, functions as a transcription regulator by direct binding to promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH. Negatively autoregulates its expression. | Delta-aminolevulinic acid dehydratase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.740 |
| arsS | HP_0162 | HP_0164 | HP_0162 | Signal-transducing protein, histidine kinase; Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of ArsR. In turn, ArsR binds to the upstream promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH. Participates [...] | Conserved hypothetical protein; Similar to PID:1183839 percent identity: 36.65; identified by sequence similarity; putative. | 0.684 |
| arsS | arsR | HP_0164 | HP_0166 | Signal-transducing protein, histidine kinase; Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of ArsR. In turn, ArsR binds to the upstream promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH. Participates [...] | Response regulator (ompR); Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways. Upon phosphorylation by ArsS, functions as a transcription regulator by direct binding to promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH. Negatively autoregulates its expression. | 0.981 |
| arsS | hemB | HP_0164 | HP_0163 | Signal-transducing protein, histidine kinase; Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of ArsR. In turn, ArsR binds to the upstream promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH. Participates [...] | Delta-aminolevulinic acid dehydratase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.713 |
| atpD | hemB | HP_1132 | HP_0163 | ATP synthase F1, subunit beta (atpD); Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. | Delta-aminolevulinic acid dehydratase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.723 |
| hemA | HP_1224 | HP_0239 | HP_1224 | glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Uroporphyrinogen III cosynthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.624 |
| hemA | hemB | HP_0239 | HP_0163 | glutamyl-tRNA reductase (hemA); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Delta-aminolevulinic acid dehydratase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.900 |
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