STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
arsSSignal-transducing protein, histidine kinase; Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of ArsR. In turn, ArsR binds to the upstream promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH. Participates [...] (254 aa)    
Predicted Functional Partners:
HP_0165
Predicted coding region HP0165; Hypothetical protein; identified by GeneMark; putative.
 
 0.990
arsR
Response regulator (ompR); Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways. Upon phosphorylation by ArsS, functions as a transcription regulator by direct binding to promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH. Negatively autoregulates its expression.
 
 0.981
cheV1
Chemotaxis protein (cheV); Plays an essential role in chemotaxis signal transduction system in order to colonize the host stomach. May act as a phosphate sink to control the flow of phosphate to CheAY.
   
 0.827
cheV3
Chemotaxis protein (cheV); Plays a role in chemotaxis signal transduction system in order to colonize the host stomach. May act as a phosphate sink to control the flow of phosphate to CheAY.
   
 0.827
cheV2
Chemotaxis protein (cheV); Plays a role in chemotaxis signal transduction system in order to colonize the host stomach. May act as a phosphate sink to control the flow of phosphate to CheAY.
   
 0.827
cheAY
Histidine kinase (cheA); Member of the two-component regulatory system CheAY/CheY that regulates chemotaxis and colonization of the gastric mucosa. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of CheY. In turn, phosphorylated CheY (CheY-P) interacts with the flagellar motor protein FliM to cause clockwise flagellar rotation and bacterial reversals, as opposed to straight swimming when CheY is not phosphorylated (By similarity).
   
 0.817
crdS
Signal-transducing protein, histidine kinase; Member of the two-component regulatory system CrdR/CrdS that induces the transcriptional induction of the copper resistance determinant CrdA in response to increasing concentrations of copper ions. Functions as a sensor protein kinase that phosphorylates CrdR (Probable). In turn, CrdR functions as a transcriptional regulator by direct binding to promoter regions of target genes including the crdA promoter or nitric oxide-responsive gene promoters.
  
 0.768
crdR
Response regulator; Member of the two-component regulatory system CrdR/CrdS that induces the transcriptional induction of the copper resistance determinant CrdA. Upon phosphorylation by CrdS, functions as a transcriptional regulator by direct binding to promoter regions of target genes including the crdA promoter or nitric oxide- responsive gene promoters.
 
 0.733
HP_1043
Response regulator; Similar to PID:929822 percent identity: 26.82; identified by sequence similarity; putative.
 
 0.728
hemB
Delta-aminolevulinic acid dehydratase (hemB); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
     
 0.713
Your Current Organism:
Helicobacter pylori
NCBI taxonomy Id: 85962
Other names: H. pylori 26695, Helicobacter pylori (strain 26695), Helicobacter pylori 26695, Helicobacter pylori ATCC 700392, Helicobacter pylori KE26695, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.