Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HP_0280Heat shock protein B (ibpB); Similar to SP:P24187 GB:X61000 PID:48957 GB:U00096 PID:1651518 percent identity: 27.23; identified by sequence similarity; putative. (328 aa)    
Predicted Functional Partners:
HP_0957
3-deoxy-d-manno-octulosonic-acid transferase (kdtA); Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
  
 0.976
HP_0279
Lipopolysaccharide heptosyltransferase-1 (rfaC); Similar to SP:P24173 GB:X62530 PID:42715 PID:466759 GB:U00096 percent identity: 31.65; identified by sequence similarity; putative.
 
   
 0.899
lpxB
Lipid A disaccharide synthetase (lpxB); Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.826
HP_0278
Guanosine pentaphosphate phosphohydrolase (gppA); Similar to GB:M87049 SP:P25552 GB:M83316 PID:148183 PID:146252 percent identity: 26.30; identified by sequence similarity; putative.
       0.818
HP_0277
Ferredoxin; Similar to GB:M93695 PID:148685 percent identity: 52.50; identified by sequence similarity; putative.
       0.809
lpxA
UDP-N-acetylglucosamine acyltransferase (lpxA); Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.752
lpxD
UDP-3-0-(3-hydroxymyristoyl) glucosamine N-acyltransferase (lpxD); Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
 
   
 0.740
lpxK
Conserved hypothetical protein; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
 
  
 0.740
HP_0270
Predicted coding region HP0270; Hypothetical protein; identified by GeneMark; putative.
 
     0.738
lpxC
UDP-3-0-acyl N-acetylglcosamine deacetylase (envA); Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.
 
   
 0.738
Your Current Organism:
Helicobacter pylori
NCBI taxonomy Id: 85962
Other names: H. pylori 26695, Helicobacter pylori (strain 26695), Helicobacter pylori 26695, Helicobacter pylori ATCC 700392, Helicobacter pylori KE26695, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695
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