STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
amiEAliphatic amidase (aimE); Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia. Hydrolyzes propionamide, acetamide and acrylamide, but has no activity with formamide or urea. The natural substrates of AmiE in its gastric environment are not known. Probably functions to ensure nitrogen supply to the bacteria. (339 aa)    
Predicted Functional Partners:
HP_0289
Toxin-like outer membrane protein; Similar to SP:Q48245 PID:2228502 PID:2327044 PID:2327046 PID:471729 percent identity: 30.59; identified by sequence similarity; putative.
   
   0.600
HP_0291
Predicted coding region HP0291; Hypothetical protein; identified by GeneMark; putative.
  
 
 0.596
HP_0056
Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family.
   
 0.574
lysA
Diaminopimelate decarboxylase (dap decarboxylase) (lysA); Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
  
 
 0.563
guaA
GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP.
     
 0.523
HP_1399
Arginase (rocF); Similar to GB:X81802 SP:P39138 PID:550313 PID:1064805 GB:AL009126 percent identity: 31.80; identified by sequence similarity; putative; Belongs to the arginase family.
   
 0.511
ureI
Urease accessory protein (ureI); Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for the adaptation of urease activity to the extracellular pH, as in the presence of urea, UreI rapidly enhances the production of ammonia in the extracellular medium when the pH of the medium was decreased to pH5 or below.
  
  
 0.494
HP_0293
Para-aminobenzoate synthetase (pabB); Similar to GB:K02673 SP:P05041 GB:U07748 GB:U07749 GB:U07755 percent identity: 35.09; identified by sequence similarity; putative.
  
 
 0.484
HP_0292
Predicted coding region HP0292; Hypothetical protein; identified by GeneMark; putative.
       0.448
aspA
Aspartate ammonia-lyase (aspA); Similar to GB:U14003 SP:P04422 GB:L20944 GB:X02307 GB:X04066 percent identity: 55.53; identified by sequence similarity; putative; Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.
   
 
 0.413
Your Current Organism:
Helicobacter pylori
NCBI taxonomy Id: 85962
Other names: H. pylori 26695, Helicobacter pylori (strain 26695), Helicobacter pylori 26695, Helicobacter pylori ATCC 700392, Helicobacter pylori KE26695, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.