STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HP_0323Membrane bound endonuclease (nuc); Similar to GB:U09868 PID:498885 percent identity: 31.13; identified by sequence similarity; putative. (180 aa)    
Predicted Functional Partners:
gmk
5'-guanylate kinase (gmk); Essential for recycling GMP and indirectly, cGMP.
    
  0.907
HP_0221
nifU-like protein; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
    
 
 0.861
chePep
Poly E-rich protein; Plays an essential role in chemotaxis. Regulates flagellar rotation through the formation of a complex with chemotaxis protein CheZ. Plays a major role in colonization of the stomach.
       0.660
argS
arginyl-tRNA synthetase (argS); Similar to SP:P35868 GB:Z21501 SP:P41253 GB:X54740 PID:433534 percent identity: 35.82; identified by sequence similarity; putative.
  
    0.581
tatA
Conserved hypothetical secreted protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
       0.576
ispDF
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
     
 0.515
HP_1361
Competence locus E (comE3); Similar to GB:L15202 SP:P39695 PID:289262 PID:1303798 GB:AL009126 percent identity: 27.47; identified by sequence similarity; putative.
    
 
 0.503
psd
Phosphatidylserine decarboxylase proenzyme (psd); Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
   
 0.495
HP_0333
DNA processing chain A (dprA); Similar to GB:L42023 SP:P43862 PID:1006171 PID:1221098 PID:609332 percent identity: 32.91; identified by sequence similarity; putative.
   
  
 0.493
plsC
1-acyl-glycerol-3-phosphate acyltransferase (plsC); Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.
  
 
 0.475
Your Current Organism:
Helicobacter pylori
NCBI taxonomy Id: 85962
Other names: H. pylori 26695, Helicobacter pylori (strain 26695), Helicobacter pylori 26695, Helicobacter pylori ATCC 700392, Helicobacter pylori KE26695, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.