STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HP_0339Predicted coding region HP0339; Hypothetical protein; identified by GeneMark; putative. (116 aa)    
Predicted Functional Partners:
HP_0340
Predicted coding region HP0340; Hypothetical protein; identified by GeneMark; putative.
       0.773
HP_0341
Predicted coding region HP0341; Hypothetical protein; identified by GeneMark; putative.
       0.752
HP_0338
Predicted coding region HP0338; Hypothetical protein; identified by GeneMark; putative.
  
    0.598
HP_0337
Predicted coding region HP0337; Hypothetical protein; identified by GeneMark; putative.
       0.596
HP_0342
Predicted coding region HP0342; Hypothetical protein; identified by GeneMark; putative.
  
    0.438
HP_0343
Predicted coding region HP0343; Hypothetical protein; identified by GeneMark; putative.
       0.437
HP_0344
Predicted coding region HP0344; Hypothetical protein; identified by GeneMark; putative.
       0.437
HP_0345
Predicted coding region HP0345; Hypothetical protein; identified by GeneMark; putative.
       0.437
topA
DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...]
   
   0.402
cagE
Cag pathogenicity island protein (cag23); Involved in DNA transfer. Required for induction of IL-8 in gastric epithelial cells.
   
   0.402
Your Current Organism:
Helicobacter pylori
NCBI taxonomy Id: 85962
Other names: H. pylori 26695, Helicobacter pylori (strain 26695), Helicobacter pylori 26695, Helicobacter pylori ATCC 700392, Helicobacter pylori KE26695, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.