Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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pseCSpore coat polysaccharide biosynthesis protein C; Catalyzes the second step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Uses UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose as substrate producing UDP-4-amino-4,6-dideoxy-beta-L-AltNAc. (375 aa)    
Predicted Functional Partners:
pseB
flaA1 protein; Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4- hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose.
 
 0.999
pseH
Flagellar protein G (flaG); Catalyzes the third step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Mediates N-4 acetylation of UDP-4-amino-4,6-dideoxy-beta-L-AltNAc to form UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose.
  
 
 0.966
HP_0326
CMP-N-acetylneuraminic acid synthetase (neuA); Catalyzes the fourth and sixth steps in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. The C-terminus mediates the fourth step of the pathway and catalyzes the removal of UDP from C-1 of UDP-2,4-diacetamido-2,4,6- trideoxy-beta-L-altropyranose forming 2,4-diacetamido-2,4,6-trideoxy- beta-L-altropyranose. The N-terminal part mediates the last step of the pathway by mediating activation of pseudaminic acid with CMP by forming CMP-pseudaminic acid.
  
  
 0.837
pseI
Spore coat polysaccharide biosynthesis protein E; Catalyzes the fifth step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Catalyzes the condensation of phosphoenolpyruvate with 2,4-diacetamido- 2,4,6-trideoxy-beta-l-altropyranose, forming pseudaminic acid (By similarity).
 
  
 0.825
HP_0367
Predicted coding region HP0367; Hypothetical protein; identified by GeneMark; putative.
       0.773
rho
Transcription termination factor Rho (rho); Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.
      0.732
HP_0043
Mannose-6-phosphate isomerase (pmi) or (algA); Similar to PIR:A25638 percent identity: 42.83; identified by sequence similarity; putative; Belongs to the mannose-6-phosphate isomerase type 2 family.
  
  
 0.590
HP_0421
Type 1 capsular polysaccharide biosynthesis protein J (capJ); Similar to GB:U10927 SP:P39859 PID:506706 percent identity: 29.00; identified by sequence similarity; putative.
 
  
 0.587
HP_0368
Predicted coding region HP0368; Hypothetical protein; identified by GeneMark; putative.
       0.538
fmt
methionyl-tRNA formyltransferase (fmt); Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
  
 0.515
Your Current Organism:
Helicobacter pylori
NCBI taxonomy Id: 85962
Other names: H. pylori 26695, Helicobacter pylori (strain 26695), Helicobacter pylori 26695, Helicobacter pylori ATCC 700392, Helicobacter pylori KE26695, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695
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