Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HP_1024Co-chaperone-curved DNA binding protein A (CbpA); Similar to GB:L42023 SP:P43735 PID:1007148 PID:1221366 PID:1205479 percent identity: 37.68; identified by sequence similarity; putative. (288 aa)    
Predicted Functional Partners:
dnaK
Chaperone and heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family.
 0.994
grpE
Co-chaperone and heat shock protein (grpE); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sev [...]
 
 
 0.968
HP_1025
Putative heat shock protein (hspR); Similar to GB:L29452 SP:P40183 PID:987631 percent identity: 46.15; identified by sequence similarity; putative.
  
 
 0.951
htpG
Chaperone and heat shock protein C62.5 (htpG); Molecular chaperone. Has ATPase activity.
   
 0.920
groL
Chaperone and heat shock protein (groEL); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 0.872
HP_0060
Predicted coding region HP0060; Hypothetical protein; identified by GeneMark; putative.
   
  0.869
HP_1026
Conserved hypothetical helicase-like protein; Similar to GB:L42023 SP:P45262 PID:1007831 PID:1221733 PID:1205822 percent identity: 33.90; identified by sequence similarity; putative.
       0.809
HP_1479
Predicted coding region HP1479; Hypothetical protein; identified by GeneMark; putative.
    
 0.803
rplC
Ribosomal protein L3 (rpl3); One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
  
 
   0.776
hrcA
Predicted coding region HP0111; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
  
  
 0.773
Your Current Organism:
Helicobacter pylori
NCBI taxonomy Id: 85962
Other names: H. pylori 26695, Helicobacter pylori (strain 26695), Helicobacter pylori 26695, Helicobacter pylori ATCC 700392, Helicobacter pylori KE26695, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.