STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HP_1366Type IIS restriction enzyme R protein (MBOIIR); Similar to SP:P23191 GB:X56977 PID:44182 percent identity: 37.14; identified by sequence similarity; putative. (423 aa)    
Predicted Functional Partners:
HP_1368
Type IIS restriction enzyme M2 protein (mod); Similar to SP:P29568 percent identity: 32.96; identified by sequence similarity; putative; Belongs to the N(4)/N(6)-methyltransferase family.
  
    0.758
HP_1367
Type IIS restriction enzyme M1 protein (mod); Similar to SP:P23192 GB:X56977 PID:44181 percent identity: 59.27; identified by sequence similarity; putative; Belongs to the N(4)/N(6)-methyltransferase family.
       0.755
nnr
Conserved hypothetical integral membrane protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity). In the N-terminal section; belongs to the NnrE/AIBP family.
       0.551
crdS
Signal-transducing protein, histidine kinase; Member of the two-component regulatory system CrdR/CrdS that induces the transcriptional induction of the copper resistance determinant CrdA in response to increasing concentrations of copper ions. Functions as a sensor protein kinase that phosphorylates CrdR (Probable). In turn, CrdR functions as a transcriptional regulator by direct binding to promoter regions of target genes including the crdA promoter or nitric oxide-responsive gene promoters.
       0.551
crdR
Response regulator; Member of the two-component regulatory system CrdR/CrdS that induces the transcriptional induction of the copper resistance determinant CrdA. Upon phosphorylation by CrdS, functions as a transcriptional regulator by direct binding to promoter regions of target genes including the crdA promoter or nitric oxide- responsive gene promoters.
       0.551
dnaB
Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.
       0.547
HP_0091
Type II restriction enzyme R protein (hsdR); Recognizes the double-stranded unmethylated sequence GATC and cleaves before G-1; Belongs to the type II restriction enzyme DpnII family.
      
 0.542
HP_0053
Predicted coding region HP0053; Hypothetical protein; identified by GeneMark; putative.
      
 0.491
HP_1351
Predicted coding region HP1351; Hypothetical protein; identified by GeneMark; putative.
      
 0.448
HP_1361
Competence locus E (comE3); Similar to GB:L15202 SP:P39695 PID:289262 PID:1303798 GB:AL009126 percent identity: 27.47; identified by sequence similarity; putative.
       0.437
Your Current Organism:
Helicobacter pylori
NCBI taxonomy Id: 85962
Other names: H. pylori 26695, Helicobacter pylori (strain 26695), Helicobacter pylori 26695, Helicobacter pylori ATCC 700392, Helicobacter pylori KE26695, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.