STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEK22179.1Probable macrolide-specific efflux protein macA; N-terminus: SpI(SignalPHMM); Flags: Precursor; 1 transmembrane domain; Secretion protein HlyD (TIGR01730); HlyD-like secretion proteins (Pfam 00529) (SSF111369); Secretion protein HlyD (PF00529); Protein involved in protein transporter activity and protein secretion; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (421 aa)    
Predicted Functional Partners:
AEK22178.1
Conserved hypothetical protein; N-terminus: SpI(LipoP); 1 transmembrane domain; Integral outer membrane protein TolC, efflux pump component (SSF56954); Outer membrane efflux protein (PF02321); Protein involved in transporter activity and transport.
 
 
 0.965
AEK23075.1
Macrolide export ATP-binding/permease protein macB; N-terminus: TMH(LipoP); 5 transmembrane domains; Protein of unknown function DUF214, permase predicted (PF02687).
 
  
 0.892
AEK24287.1
Macrolide export ATP-binding/permease protein macB; N-terminus: SpI(SignalPHMM); 4 transmembrane domains; Protein of unknown function DUF214, permase predicted (PF02687).
 
  
 0.892
macB
Uncharacterized ABC transporter ATP-binding protein yknY; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
 
 
 0.836
AEK22180.1
Short=PGDH; Formate/glycerate dehydrogenase catalytic domain-like (SSF52283); D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (PF00389); D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding (PF02826); NAD(P)-binding domain (G3DSA:3.40.50.720); 2-HYDROXYACID DEHYDROGENASE (PTHR10996); D-3-phosphogylcerate Dehydrogenase (PTHR10996:SF20); NAD(P)-binding domain (SSF51735); Protein involved in catalytic activity, binding, phosphoglycerate dehydrogenase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, cofactor binding, NAD [...]
  
    0.778
AEK22357.1
N-terminus: SpI(LipoP); AltName: Full=Cation efflux system protein czcC;Flags: Precursor; 1 transmembrane domain; Integral outer membrane protein TolC, efflux pump component (SSF56954); Outer membrane efflux protein (PF02321); Protein involved in transporter activity and transport.
 
 
 0.711
AEK23049.1
Outer membrane protein oprM; N-terminus: SpII(LipoP); Flags: Precursor; 1 transmembrane domain; Outer membrane efflux protein (PF02321); Integral outer membrane protein TolC, efflux pump component (SSF56954); RND efflux system, outer membrane lipoprotein, NodT (TIGR01845); Protein involved in transporter activity, lipid binding and transport.
  
 
 0.655
AEK24491.1
N-terminus: SpI(LipoP); Outer membrane efflux protein (PF02321); Integral outer membrane protein TolC, efflux pump component (SSF56954); Protein involved in transporter activity and transport.
 
 
 0.655
AEK22177.1
Conserved hypothetical protein; 2 transmembrane domains.
       0.488
AEK23644.1
Sensor protein evgS; N-terminus: TMH(LipoP); Flags: Precursor; 3 transmembrane domains; Signal transduction histidine kinase, homodimeric (SSF47384); ATPase-like, ATP-binding domain (SSF55874); TETRACYCLINE RESISTANCE ELEMENT REGULATOR RTEA - BACTEROIDES THETAIOTAOMICRON (PTHR23283:SF38); Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (SM00388); Signal transduction histidine kinase, phosphotransfer (Hpt) domain (SSF47226); Undefined Gene3D domain (G3DSA:1.10.287.240); ATPase-like, ATP-binding domain (PF02518); Signal transduction histidine kinase, [...]
  
  
 0.480
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.