STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ileSIsoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1160 aa)    
Predicted Functional Partners:
proS
Proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
  
 0.967
pheT
AltName: Full=Phenylalanine--tRNA ligase beta chain;Short=PheRS; Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding (G3DSA:3.30.70.380); tRNA synthetase, B5 (PF03484); Nucleic acid-binding, OB-fold (G3DSA:2.40.50.140); tRNA synthetase, B5 (G3DSA:3.30.56.20); Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding (SSF54991); B3/B4 tRNA-binding domain (PF03483); Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial (TIGR00472); Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding (PF03147); PHENYLALANYL [...]
  
 
 0.961
metG
Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
 
 0.936
argS
AltName: Full=Arginine--tRNA ligase;Short=ArgRS; Aminoacyl-tRNA synthetase, class I, conserved site (PS00178); Legume lectin, beta chain, Mn/Ca-binding site (PS00307); Arginyl-tRNA synthetase, class Ic (MF_00123); Arginyl-tRNA synthetase, class Ic (TIGR00456); Undefined Gene3D domain (G3DSA:1.10.730.10); Arginyl-tRNA synthetase, class Ic, core (PR01038); Rossmann-like alpha/beta/alpha sandwich fold (G3DSA:3.40.50.620); Arginyl tRNA synthetase, class Ic, N-terminal (PF03485); Arginyl-tRNA synthetase, class Ic, core (PF00750); Aminoacyl-tRNA synthetase, class 1a, anticodon-binding (SSF47 [...]
 
 0.932
lysS
AltName: Full=Lysine--tRNA ligase;Short=LysRS; Undefined Gene3D domain (G3DSA:3.30.930.10); Aminoacyl-tRNA synthetase, class II (D/K/N)-like (PTHR22594); Nucleic acid-binding, OB-fold (G3DSA:2.40.50.140); Nucleic acid binding, OB-fold, tRNA/helicase-type (PF01336); Lysyl-tRNA synthetase, class II (MF_00252); Aminoacyl-tRNA synthetase, class II (D/K/N) (PF00152); Lysyl-tRNA synthetase, class II (TIGR00499); Class II aaRS and biotin synthetases (SSF55681); Lysyl-tRNA synthetase, class II, C-terminal (PTHR22594:SF4); Lysyl-tRNA synthetase, class II, C-terminal (PR00982); Nucleic acid-bind [...]
  
 0.869
valS
Valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
  
 
0.846
gltX
Glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
 
 0.812
AEK23996.1
AltName: Full=Leucine--tRNA ligase;Short=LeuRS; Aminoacyl-tRNA synthetase, class Ia (PF00133); Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial (PTHR11946:SF7); Undefined Gene3D domain (G3DSA:1.10.730.10); ISOLEUCYL, LEUCYL, TYROSYL, VALYL AND METHIONYL-TRNA SYNTHETASES (PTHR11946); Rossmann-like alpha/beta/alpha sandwich fold (G3DSA:3.40.50.620); Aminoacyl-tRNA synthetase, class 1a, anticodon-binding (SSF47323); Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial (PR00985); Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding (PF08264); Nucleotidylyl trans [...]
  
 0.802
AEK23997.1
AltName: Full=Leucine--tRNA ligase;Short=LeuRS; Aminoacyl-tRNA synthetase, class I, conserved site (PS00178); Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial (PTHR11946:SF7); Aminoacyl-tRNA synthetase, class Ia (PF00133); ISOLEUCYL, LEUCYL, TYROSYL, VALYL AND METHIONYL-TRNA SYNTHETASES (PTHR11946); Rossmann-like alpha/beta/alpha sandwich fold (G3DSA:3.40.50.620); Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing (SSF50677); Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial (PR00985); Undefined Gene3D domain (G3DSA:3.90.740.10); Nucleotidylyl transferase (SSF52 [...]
  
0.802
alaS
Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
 
 
 0.799
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
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