STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dinBDNA polymerase IV 2; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (370 aa)    
Predicted Functional Partners:
AEK22882.1
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.844
AEK23156.1
DNA polymerase III subunit alpha; Polymerase/histidinol phosphatase-like (SSF89550); DNA (TIGR00594); Polynucleotidyl transferase, ribonuclease H fold (SSF53098); Exonuclease, RNase T/DNA polymerase III (PF00929); PHP, C-terminal (PF02811); Polymerase/histidinol phosphatase, N-terminal (SM00481); Bacterial DNA polymerase III, alpha subunit (PF07733); Nucleic acid-binding, OB-fold-like (SSF50249); Undefined Gene3D domain (G3DSA:3.30.420.10); Protein involved in DNA binding, DNA-directed DNA polymerase activity, 3'-5' exonuclease activity, nucleic acid binding, catalytic activity and DNA [...]
 
  
 0.762
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.682
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.645
gcvP
Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 
      0.625
AEK23569.1
Conserved hypothetical protein; N-terminus: SpI(SignalPHMM).
    
   0.572
AEK23226.1
Rotamase; N-terminus: SpII(LipoP); Short=PPIase;AltName: Full=Rotamase; Cyclophilin-like (SSF50891); CYCLOPHILIN (PTHR11071); Peptidyl-prolyl cis-trans isomerase, FKBP-type (PS50059); Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (PF00160); PEPTIDYL-PROLYL CIS-TRANS ISOMERASE (CYCLOPHILIN) (PTHR11071:SF35); Undefined Gene3D domain (G3DSA:3.10.50.40); Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (PR00153); Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (PS00170); Peptidyl-prolyl cis-trans isomerase, FKBP-type (PF00254); FKBP-like (SSF54534); Pepti [...]
 
 
 0.520
AEK23334.1
Rotamase; Short=PPIase;AltName: Full=Rotamase; Cyclophilin-like (SSF50891); CYCLOPHILIN (PTHR11071); Peptidyl-prolyl cis-trans isomerase, FKBP-type (PS50059); Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (PF00160); PEPTIDYL-PROLYL CIS-TRANS ISOMERASE (CYCLOPHILIN) (PTHR11071:SF35); Undefined Gene3D domain (G3DSA:3.10.50.40); Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (PR00153); Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (PS00170); Peptidyl-prolyl cis-trans isomerase, FKBP-type (PF00254); Peptidyl-prolyl cis-trans isomerase, cyclophilin-typ [...]
 
 
 0.508
AEK22644.1
Uncharacterized AAA family ATPase y4kL; Undefined Gene3D domain (G3DSA:3.40.50.300); P-loop containing nucleoside triphosphate hydrolases (SSF52540); 26S PROTEASE REGULATORY SUBUNIT (PTHR23073); ATPase, AAA-type, core (PF00004); ATPase, AAA+ type, core (SM00382); Protein involved in nucleotide binding, nucleoside-triphosphatase activity and ATP binding.
   
 
 0.464
AEK23344.1
Conserved hypothetical protein; N-terminus: SpI(LipoP).
   
 
 0.457
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.