STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
AEK22370.1Succinate dehydrogenase iron-sulfur subunit; Beta-grasp fold, ferredoxin-type (G3DSA:3.10.20.30); Alpha-helical ferredoxin (SSF46548); SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (PTHR11921); Ferredoxin (SSF54292); 4Fe-4S ferredoxin, iron-sulpur binding domain (PS51379); 2Fe-2S ferredoxin, iron-sulphur binding site (PS00197); Fumarate reductase, C-terminal (G3DSA:1.10.1060.10); Protein involved in oxidoreductase activity, iron-sulfur cluster binding, electron carrier activity and oxidation reduction. (229 aa)    
Predicted Functional Partners:
AEK22373.1
Undefined Gene3D domain (G3DSA:3.50.50.60); Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal (PF02910); Succinate (PTHR11632:SF4); Succinate (TIGR01811); Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal (SSF46977); Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (SSF56425); FAD/NAD(P)-binding domain (SSF51905); Undefined Gene3D domain (G3DSA:1.20.58.100); Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal (PF00890); SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT (PTHR11632); Protein involved in electr [...]
 
 0.999
AEK22374.1
N-terminus: TMH(LipoP); Flags: Precursor; 5 transmembrane domains; Succinate dehydrogenase, cytochrome b558 subunit (TIGR02046); Succinate dehydrogenase/Fumarate reductase, transmembrane subunit (PF01127); Fumarate reductase respiratory complex transmembrane subunits (SSF81343); Protein involved in oxidoreductase activity, acting on the CH-CH group of donors.
 
 
 0.996
sucD
Vegetative protein 239; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.983
sucC
Succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.977
fumC
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.963
AEK22318.1
4Fe-4S ferredoxins (SSF54862); Undefined Gene3D domain (G3DSA:3.30.70.20); 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (PS00198); 4Fe-4S ferredoxin, iron-sulpur binding domain (PS51379); Fer4 (PF00037); Protein involved in electron carrier activity and iron-sulfur cluster binding.
   
 
 0.909
AEK22410.1
AltName: Full=Alpha-ketoglutarate dehydrogenase; Thiamin diphosphate-binding fold (THDP-binding) (SSF52518); Undefined Gene3D domain (G3DSA:3.40.50.970); Dehydrogenase, E1 component (PF00676); 2-oxoglutarate dehydrogenase, E1 component (PTHR23152); Transketolase-like, pyrimidine-binding domain (PF02779); 2-oxoglutarate (PIRSF000157); 2-oxoglutarate dehydrogenase, E1 component (TIGR00239); Protein involved in oxoglutarate dehydrogenase (succinyl-transferring) activity, thiamin pyrophosphate binding, oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acc [...]
  
 
 0.879
atpG
F-ATPase gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
  
 
 0.870
AEK23466.1
Citrate synthase-like, core (SSF48256); Citrate synthase-like (PR00143); Citrate synthase, type II (TIGR01798); Citrate synthase active site (PS00480); Citrate synthase-like, large alpha subdomain (G3DSA:1.10.580.10); Citrate synthase-like (PTHR11739); Citrate synthase-like (PF00285); Protein involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer, citrate (Si)-synthase activity, cellular carbohydrate metabolic process and tricarboxylic acid cycle.
  
 
 0.867
AEK23605.1
Beta-diketonase; Short=FAA;AltName: Full=Fumarylacetoacetate hydrolase;AltName: Full=Beta-diketonase; FUMARYLACETOACETATE HYDROLASE (PTHR11820); Fumarylacetoacetase, N-terminal (SSF63433); Fumarylacetoacetase, C-terminal-related (SSF56529); Fumarylacetoacetase, C-terminal-like (PF01557); Fumarylacetoacetase (PTHR11820:SF1); Fumarylacetoacetase, N-terminal (PF09298); Fumarylacetoacetase (TIGR01266); Fumarylacetoacetase, C-terminal-related (G3DSA:3.90.850.10); Protein involved in catalytic activity, fumarylacetoacetase activity, metabolic process and aromatic amino acid family metabolic [...]
  
 
  0.809
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
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