STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEK22395.1Short=PK; Pyruvate kinase, alpha/beta (PF02887); Pyruvate/Phosphoenolpyruvate kinase, catalytic core (G3DSA:3.20.20.60); Pyruvate kinase (TIGR01064); Pyruvate kinase, beta-barrel-like (SSF50800); Pyruvate kinase, barrel (PR01050); Pyruvate/Phosphoenolpyruvate kinase, catalytic core (SSF51621); Pyruvate kinase, barrel (PF00224); Pyruvate kinase (PTHR11817); Pyruvate kinase, C-terminal-like (SSF52935); Pyruvate kinase, active site (PS00110); Pyruvate kinase, alpha/beta (G3DSA:3.40.1380.20); Protein involved in catalytic activity, magnesium ion binding, pyruvate kinase activity, potassium [...] (480 aa)    
Predicted Functional Partners:
eno
2-phospho-D-glycerate hydro-lyase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 0.988
pgi
Phosphohexose isomerase; Short=GPI;AltName: Full=Phosphoglucose isomerase;Short=PGI;AltName: Full=Phosphohexose isomerase;Short=PHI; Phosphoglucose isomerase (PGI) (MF_00473); Phosphoglucose isomerase, conserved site (PS00765); Undefined Gene3D domain (G3DSA:1.10.1390.10); Phosphoglucose isomerase (PGI) (PF00342); Phosphoglucose isomerase (PGI) (PTHR11469); Phosphoglucose isomerase, conserved site (PS00174); Undefined Gene3D domain (G3DSA:3.40.50.10490); Phosphoglucose isomerase (PGI) (PR00662); SIS domain (SSF53697); Protein involved in glucose-6-phosphate isomerase activity, gluconeo [...]
  
 
 0.975
AEK24012.1
Short=NADP-ME; Malic enzyme, NAD-binding (PF03949); NAD(P)-binding domain (G3DSA:3.40.50.720); Malic (PIRSF036684); Aminoacid dehydrogenase-like, N-terminal domain (SSF53223); MALIC ENZYME-RELATED (PTHR23406); Undefined Gene3D domain (G3DSA:3.40.50.10380); Isocitrate/Isopropylmalate dehydrogenase-like (SSF53659); Malic enzyme, N-terminal (PF00390); Phosphate acetyl/butaryl transferase (PF01515); MALIC ENZYME (PTHR23406:SF2); NAD(P)-binding domain (SSF51735); Protein involved in catalytic activity, binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acc [...]
  
 0.971
rplB
50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
  
 
 0.954
rplE
50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
  
 
 0.953
rplJ
50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.
  
   0.953
rplX
50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
  
   0.952
AEK22566.1
50S ribosomal protein L23; Nucleotide-binding, alpha-beta plait (G3DSA:3.30.70.330); Ribosomal protein L25/L23 (PF00276); Ribosomal protein L23/L15e, core (SSF54189); Protein involved in structural constituent of ribosome, nucleotide binding and translation.
  
 
 0.950
rplR
50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
  
 
 0.950
rplN
50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
  
   0.946
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
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