STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
alaSAlanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (878 aa)    
Predicted Functional Partners:
AEK22484.1
Hypothetical protein; Weak similarity to UniProt:Q00808; N-terminus: SpI(SignalPHMM); Locus: Belongs to PUL_3; WD40 repeat-like-containing domain (SSF50978); WD40/YVTN repeat-like-containing domain (G3DSA:2.130.10.10); WD40 repeat (SM00320); WD40 repeat, conserved site (PS00678); WD40 REPEAT PROTEIN (PTHR19877).
  
 0.910
pheT
AltName: Full=Phenylalanine--tRNA ligase beta chain;Short=PheRS; Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding (G3DSA:3.30.70.380); tRNA synthetase, B5 (PF03484); Nucleic acid-binding, OB-fold (G3DSA:2.40.50.140); tRNA synthetase, B5 (G3DSA:3.30.56.20); Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding (SSF54991); B3/B4 tRNA-binding domain (PF03483); Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial (TIGR00472); Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding (PF03147); PHENYLALANYL [...]
 
 
 0.852
metG
Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
 
  
 0.844
secF
Protein-export membrane protein secD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
  
    0.814
valS
Valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
 
  
 0.810
ileS
Isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
 
 
 0.799
thrS
Threonine--tRNA ligase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).
  
 
 0.772
purL
Formylglycinamide ribotide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
 
    0.759
AEK22189.1
Hypothetical protein; Weak similarity to UniProt:Q8CGY8; Tetratricopeptide repeat (SM00028); TPR-like (SSF48452); Tetratricopeptide repeat-containing (PS50293); TETRATRICOPEPTIDE REPEAT PROTEIN, TPR (PTHR23083:SF20); Tetratricopeptide repeat (PS50005); Tetratricopeptide-like helical (G3DSA:1.25.40.10); TETRATRICOPEPTIDE REPEAT PROTEIN, TPR (PTHR23083); Tetratricopeptide TPR-1 (PF00515); Protein involved in binding.
   
 0.758
AEK22301.1
TPR repeat-containing protein; N-terminus: SpII(LipoP); 1 transmembrane domain; Tetratricopeptide repeat (SM00028); TPR-like (SSF48452); Tetratricopeptide repeat-containing (PS50293); Tetratricopeptide repeat (PS50005); Tetratricopeptide-like helical (G3DSA:1.25.40.10); Tetratricopeptide (SM00028); Protein involved in binding.
   
 0.758
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
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