STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
kdsBCMP-2-keto-3-deoxyoctulosonic acid synthase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (244 aa)    
Predicted Functional Partners:
AEK22185.1
KDO transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
  
 0.983
AEK23131.1
AltName: Full=KDO 8-P phosphatase; Phosphatase KdsC (TIGR01670); Undefined Gene3D domain (G3DSA:3.40.50.1000); HAD-like (SSF56784); Nitrogenase component 1, conserved site (PS00699); HAD superfamily hydrolase-like, type 3 (PF08282); CMP-N-ACETYLNEURAMINIC ACID SYNTHASE (PTHR21485); 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (PIRSF006118); HAD-superfamily hydrolase, subfamily IIIA (TIGR01662); N-ACYLNEURAMINATE-9-PHOSPHATASE (PTHR21485:SF10); Protein involved in 3-deoxy-manno-octulosonate-8-phosphatase activity, nitrogenase activity, lipopolysaccharide biosynthetic process and [...]
 
  
 0.968
AEK23333.1
Arabinose 5-phosphate isomerase; Sugar isomerase (SIS) (PF01380); Cystathionine beta-synthase, core (PS51371); GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE (PTHR10937); KpsF/GutQ (TIGR00393); Cystathionine (SM00116); Undefined Gene3D domain (G3DSA:3.40.50.10490); Cystathionine beta-synthase, core (SM00116); Cystathionine beta-synthase, core (PF00571); SIS domain (SSF53697); Protein involved in isomerase activity, sugar binding and carbohydrate metabolic process; Belongs to the SIS family. GutQ/KpsF subfamily.
 
   
 0.875
AEK24099.1
KDO-8-phosphate synthase; AltName: Full=Phospho-2-dehydro-3-deoxyoctonate aldolase;AltName: Full=3-deoxy-D-manno-octulosonic acid 8-phosphate synthase;AltName: Full=KDO-8-phosphate synthase;Short=KDO 8-P synthase;Short=KDOPS; 3-deoxy-8-phosphooctulonate synthase (TIGR01362); Aldolase-type TIM barrel (G3DSA:3.20.20.70); Aldolase (SSF51569); 3-deoxy-8-phosphooctulonate synthase (PTHR21057:SF2); DAHP synthetase I/KDSA (PF00793); PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE (PTHR21057); Protein involved in 3-deoxy-8-phosphooctulonate synthase activity, catalytic activity, metabolic process [...]
 
   
 0.841
lpxK
Lipid A 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
 
   
 0.837
AEK23078.1
Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.826
AEK23495.1
Acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.821
lpxD
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
 
   
 0.765
AEK23499.1
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE (PTHR22572:SF15); Bacterial transferase hexapeptide repeat (PF00132); Undefined Gene3D domain (G3DSA:2.160.10.10); Trimeric LpxA-like (SSF51161); Hexapeptide transferase, conserved site (PS00101); UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, non-repeat region (PF04613); UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase (TIGR01853); SUGAR-1-PHOSPHATE GUANYL TRANSFERASE (PTHR22572); Protein involved in transferase activity, transferase activity, transferring acyl grou [...]
 
   
 0.729
fabZ
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily.
 
   
 0.668
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
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