STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
sucDVegetative protein 239; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (279 aa)    
Predicted Functional Partners:
sucC
Succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
AEK22370.1
Succinate dehydrogenase iron-sulfur subunit; Beta-grasp fold, ferredoxin-type (G3DSA:3.10.20.30); Alpha-helical ferredoxin (SSF46548); SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (PTHR11921); Ferredoxin (SSF54292); 4Fe-4S ferredoxin, iron-sulpur binding domain (PS51379); 2Fe-2S ferredoxin, iron-sulphur binding site (PS00197); Fumarate reductase, C-terminal (G3DSA:1.10.1060.10); Protein involved in oxidoreductase activity, iron-sulfur cluster binding, electron carrier activity and oxidation reduction.
  
 0.983
AEK22373.1
Undefined Gene3D domain (G3DSA:3.50.50.60); Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal (PF02910); Succinate (PTHR11632:SF4); Succinate (TIGR01811); Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal (SSF46977); Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (SSF56425); FAD/NAD(P)-binding domain (SSF51905); Undefined Gene3D domain (G3DSA:1.20.58.100); Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal (PF00890); SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT (PTHR11632); Protein involved in electr [...]
  
 0.979
AEK22316.1
2-oxoglutarate dehydrogenase complex component E2; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
  
 0.965
AEK22825.1
Branched-chain alpha-keto acid dehydrogenase complex component E2; AltName: Full=Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase;AltName: Full=Dihydrolipoamide branched chain transacylase;AltName: Full=Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex;AltName: Full=Branched-chain alpha-keto acid dehydrogenase complex component E2;Short=BCKAD-E2;Short=BCKADE2; E3 binding (PF02817); Undefined Gene3D domain (G3DSA:2.40.50.100); Biotin/lipoyl attachment (PS50968); DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED (PTHR23151); [...]
  
 0.965
AEK22410.1
AltName: Full=Alpha-ketoglutarate dehydrogenase; Thiamin diphosphate-binding fold (THDP-binding) (SSF52518); Undefined Gene3D domain (G3DSA:3.40.50.970); Dehydrogenase, E1 component (PF00676); 2-oxoglutarate dehydrogenase, E1 component (PTHR23152); Transketolase-like, pyrimidine-binding domain (PF02779); 2-oxoglutarate (PIRSF000157); 2-oxoglutarate dehydrogenase, E1 component (TIGR00239); Protein involved in oxoglutarate dehydrogenase (succinyl-transferring) activity, thiamin pyrophosphate binding, oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acc [...]
  
 0.946
AEK23037.1
M2 antigen complex 70 kDa subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.931
AEK23204.1
Putative methylmalonyl-CoA mutase small subunit; METHYLMALONYL-COA MUTASE (PTHR23408:SF1); METHYLMALONYL-COA MUTASE (PTHR23408); Methylmalonyl-CoA mutase, alpha/beta chain, catalytic (PF01642); Cobalamin (vitamin B12)-dependent enzyme, catalytic (SSF51703); Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain (G3DSA:3.20.20.240); Protein involved in catalytic activity, cobalamin binding, intramolecular transferase activity and metabolic process.
    
 0.916
AEK22374.1
N-terminus: TMH(LipoP); Flags: Precursor; 5 transmembrane domains; Succinate dehydrogenase, cytochrome b558 subunit (TIGR02046); Succinate dehydrogenase/Fumarate reductase, transmembrane subunit (PF01127); Fumarate reductase respiratory complex transmembrane subunits (SSF81343); Protein involved in oxidoreductase activity, acting on the CH-CH group of donors.
    
 0.915
AEK23576.1
Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
 
 0.877
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
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