STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
AEK22456.1Pre-uroporphyrinogen synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (305 aa)    
Predicted Functional Partners:
AEK22598.1
Hydroxymethylbilane hydrolyase (cyclizing); Includes:RecName: Full=Uroporphyrinogen-III C-methyltransferase;Short=Urogen III methylase;AltName: Full=SUMT;AltName: Full=Uroporphyrinogen III methylase;Short=UROM;Includes:RecName: Full=Uroporphyrinogen-III synthase;Short=UROS;AltName: Full=Uroporphyrinogen-III cosynthetase;AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing]; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase (SSF69618); Tetrapyrrole biosynthesis, uroporphyrinogen III synthase (PF02602); Undefined Gene3D domain (G3DSA:3.40.50.10090); UROPORPHYRINOGEN III SYNTHAS [...]
 0.997
AEK22507.1
Porphobilinogen synthase; Short=ALADH;Short=ALAD;AltName: Full=Porphobilinogen synthase; Tetrapyrrole biosynthesis, porphobilinogen synthase (PS00169); Aldolase-type TIM barrel (G3DSA:3.20.20.70); Aldolase (SSF51569); Tetrapyrrole biosynthesis, porphobilinogen synthase (PIRSF001415); Tetrapyrrole biosynthesis, porphobilinogen synthase (PF00490); Tetrapyrrole biosynthesis, porphobilinogen synthase (PTHR11458); Tetrapyrrole biosynthesis, porphobilinogen synthase (PR00144); Protein involved in porphobilinogen synthase activity, metal ion binding, catalytic activity, tetrapyrrole biosynthe [...]
 
 0.994
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.993
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.987
AEK22438.1
Uroporphyrinogen-III cosynthase; Short=UROS;AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing];AltName: Full=Uroporphyrinogen-III cosynthase; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase (SSF69618); Tetrapyrrole biosynthesis, uroporphyrinogen III synthase (PF02602); UROPORPHYRINOGEN III SYNTHASE (PTHR12390); Protein involved in uroporphyrinogen-III synthase activity and tetrapyrrole biosynthetic process.
  
 0.970
hemL
Short=GSA;AltName: Full=Glutamate-1-semialdehyde aminotransferase;Short=GSA-AT; Aminotransferase class-III (PF00202); GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE (PTHR11986:SF5); Pyridoxal phosphate-dependent transferase, major domain (SSF53383); Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase (TIGR00713); Aminotransferase class-III (PTHR11986); Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (G3DSA:3.40.640.10); Aminotransferase class-III (PS00600); Protein involved in glutamate-1-semialdehyde 2,1-aminomutase activity, catalytic activity, pyridox [...]
 
  
 0.913
AEK22458.1
Regulatory protein pchR; Helix-turn-helix, AraC type (PF00165); Helix-turn-helix, AraC domain (PS01124); ARAC FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN (PTHR11019:SF11); Helix-turn-helix, AraC domain (SM00342); Helix-turn-helix, AraC type, subdomain 2 (PS00041); Homeodomain-like (SSF46689); THIJ/PFPI (PTHR11019); Helix-turn-helix, AraC (PR00032); Protein involved in transcription factor activity, sequence-specific DNA binding and regulation of transcription, DNA-dependent.
       0.550
AEK22455.1
Hypothetical protein.
       0.488
hemH
Heme synthase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
  
 0.467
fusA
Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
 
 
  
 0.464
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
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