STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEK23265.1AltName: Full=Ribonucleotide reductase large subunit; Ribonucleotide reductase large subunit, C-terminal (PF02867); PFL-like glycyl radical enzymes (SSF51998); Undefined Gene3D domain (G3DSA:3.90.244.10); Ribonucleoside-diphosphate reductase alpha chain (TIGR02510); Ribonucleotide reductase large subunit, C-terminal (PTHR11573); Ribonucleotide reductase large subunit, C-terminal (PR01183); Protein involved in ribonucleoside-diphosphate reductase activity and DNA replication. (551 aa)    
Predicted Functional Partners:
AEK23266.1
AltName: Full=Ribonucleotide reductase small subunit; Ribonucleotide reductase-related (G3DSA:1.10.620.20); RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN (PTHR23409:SF5); Ribonucleotide reductase (PF00268); Ferritin/ribonucleotide reductase-like (SSF47240); Ribonucleotide reductase (PTHR23409); Protein involved in ribonucleoside-diphosphate reductase activity, oxidoreductase activity, transition metal ion binding, deoxyribonucleoside diphosphate metabolic process and oxidation reduction.
 
 0.999
AEK23151.1
Protein of unknown function DUF179 (PF02622).
   
 0.973
adk
ATP-AMP transphosphorylase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
 
 0.941
cmk
Short=CK;AltName: Full=Cytidine monophosphate kinase;Short=CMP kinase; P-loop containing nucleoside triphosphate hydrolases (SSF52540); CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE (PTHR21299); Undefined Gene3D domain (G3DSA:3.40.50.300); Cytidylate kinase (MF_00238); Cytidylate kinase domain (PF02224); Cytidylate kinase (TIGR00017); Cytidylate kinase (PTHR21299:SF2); Protein involved in cytidylate kinase activity, ATP binding and nucleobase, nucleoside, nucleotide and nucleic acid metabolic process.
  
 
 0.919
AEK22539.1
Short=NDK;Short=NDP kinase;AltName: Full=Nucleoside-2-P kinase; Nucleoside diphosphate kinase, core (PR01243); Nucleoside diphosphate kinase, core (G3DSA:3.30.70.141); Nucleoside diphosphate kinase, core (SSF54919); Nucleoside diphosphate kinase, core (PTHR11349); Nucleoside diphosphate kinase, core (SM00562); Nucleoside diphosphate kinase, core (PS00469); Nucleoside diphosphate kinase, core (PF00334); Protein involved in nucleoside diphosphate kinase activity, ATP binding, GTP biosynthetic process, UTP biosynthetic process and CTP biosynthetic process.
     
 0.915
gmk
GMP kinase; Essential for recycling GMP and indirectly, cGMP.
     
 0.912
AEK22395.1
Short=PK; Pyruvate kinase, alpha/beta (PF02887); Pyruvate/Phosphoenolpyruvate kinase, catalytic core (G3DSA:3.20.20.60); Pyruvate kinase (TIGR01064); Pyruvate kinase, beta-barrel-like (SSF50800); Pyruvate kinase, barrel (PR01050); Pyruvate/Phosphoenolpyruvate kinase, catalytic core (SSF51621); Pyruvate kinase, barrel (PF00224); Pyruvate kinase (PTHR11817); Pyruvate kinase, C-terminal-like (SSF52935); Pyruvate kinase, active site (PS00110); Pyruvate kinase, alpha/beta (G3DSA:3.40.1380.20); Protein involved in catalytic activity, magnesium ion binding, pyruvate kinase activity, potassium [...]
     
 0.905
AEK23296.1
(p)ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
 0.900
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
  
 0.802
AEK22882.1
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 
 0.767
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
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