STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
recGATP-dependent DNA helicase recG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (701 aa)    
Predicted Functional Partners:
AEK23553.1
Conserved hypothetical protein; 1 transmembrane domain.
       0.752
topA
Swivelase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Fi [...]
  
  
 0.668
AEK23556.1
UPF0001 protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
       0.612
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
   
 0.612
AEK23555.1
Uncharacterized oxidoreductase yisS; Oxidoreductase, N-terminal (PF01408); NAD(P)-binding domain (G3DSA:3.40.50.720); Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (SSF55347); OXIDOREDUCTASES (PTHR22604); OXIDOREDUCTASE (PTHR22604:SF14); NAD(P)-binding domain (SSF51735); Protein involved in catalytic activity, binding, oxidoreductase activity and metabolic process.
       0.598
AEK22761.1
ATP-dependent DNA helicase pcrA; Undefined Gene3D domain (G3DSA:3.40.50.300); P-loop containing nucleoside triphosphate hydrolases (SSF52540); DNA helicase, UvrD-like, C-terminal (PS51217); Helicase, superfamily 1, UvrD-related (PS51198); DNA helicase, UvrD/REP type (PF00580); DNA helicase, UvrD/REP type (PTHR11070); Protein involved in ATP binding, hydrolase activity, DNA binding, ATP-dependent DNA helicase activity and DNA repair.
 
  
 0.540
miaA
Dimethylallyl diphosphate:tRNA dimethylallyltransferase 1; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family.
  
     0.508
AEK23745.1
Hypothetical protein; THREE PRIME REPAIR EXONUCLEASE 2 (PTHR13058:SF5); Excinuclease ABC, C subunit, N-terminal (SM00465); Excinuclease ABC, C subunit, N-terminal (SSF82771); Polynucleotidyl transferase, ribonuclease H fold (SSF53098); Exonuclease, RNase T/DNA polymerase III (PF00929); DNA polymerase III, epsilon subunit (TIGR00573); Excinuclease ABC, C subunit, N-terminal (PF01541); Excinuclease ABC, C subunit, N-terminal (PS50164); THREE PRIME REPAIR EXONUCLEASE 1, 2 (PTHR13058); Exonuclease (SM00479); Undefined Gene3D domain (G3DSA:3.30.420.10); Protein involved in nuclease activity [...]
  
  
 0.490
dnaA
Chromosomal replication initiator protein dnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
  
   
 0.480
recR
Recombination protein recR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
  
   
 0.475
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
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