STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEK23717.1HTP reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (348 aa)    
Predicted Functional Partners:
AEK22327.1
Riboflavin synthase alpha chain; Lumazine-binding protein (PS51177); Lumazine-binding protein (PIRSF000498); Riboflavin synthase-like beta-barrel (SSF63380); Lumazine-binding protein (PTHR21098); Lumazine-binding protein (PF00677); Lumazine-binding protein (TIGR00187); Undefined Gene3D domain (G3DSA:2.40.30.20).
  
 0.999
ribB
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
 0.999
ribH
Riboflavin synthase beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 
 0.992
AEK23716.1
IMPACT family member yvyE; Ribosomal protein S5 domain 2-type fold (SSF54211); Undefined Gene3D domain (G3DSA:3.30.230.30); Uncharacterised protein family UPF0029, Impact, N-terminal (PF01205); Uncharacterised protein family UPF0029, Impact, N-terminal (PTHR16301).
       0.849
AEK22597.1
Short=DGUO kinase;Short=dGK; P-loop containing nucleoside triphosphate hydrolases (SSF52540); Undefined Gene3D domain (G3DSA:3.40.50.300); Deoxynucleoside kinase (PTHR10513); Deoxynucleoside kinase (PF01712); 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK (G3DSA:3.30.70.560); 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK (SSF55083); 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK (TIGR01498); 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK (PF01288); DEOXYGUANOSINE KINASE/DEOXYADENOSINE KINASE (PTHR10513:SF3); Protein involved in 2-amino-4-hyd [...]
 
  
 0.773
guaA
GMP synthetase; Catalyzes the synthesis of GMP from XMP.
     
 0.738
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.724
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.712
prmC
tRNA(m7G46)-methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
       0.703
AEK23333.1
Arabinose 5-phosphate isomerase; Sugar isomerase (SIS) (PF01380); Cystathionine beta-synthase, core (PS51371); GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE (PTHR10937); KpsF/GutQ (TIGR00393); Cystathionine (SM00116); Undefined Gene3D domain (G3DSA:3.40.50.10490); Cystathionine beta-synthase, core (SM00116); Cystathionine beta-synthase, core (PF00571); SIS domain (SSF53697); Protein involved in isomerase activity, sugar binding and carbohydrate metabolic process; Belongs to the SIS family. GutQ/KpsF subfamily.
     
 0.693
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
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