STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
AEK24380.1Nuclease sbcCD subunit C; Undefined Gene3D domain (G3DSA:3.40.50.300); P-loop containing nucleoside triphosphate hydrolases (SSF52540); Undefined BlastProDom domain (PD936484). (1240 aa)    
Predicted Functional Partners:
sbcD
Nuclease sbcCD subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
 
 0.995
AEK23758.1
Hypothetical protein; Weak similarity to UniProt:Q45600; P-loop containing nucleoside triphosphate hydrolases (SSF52540); Metallo-dependent phosphatases (SSF56300); Undefined Gene3D domain (G3DSA:3.60.21.10); Metallophosphoesterase (PF00149); Protein involved in hydrolase activity.
  
 0.913
AEK24204.1
Hypothetical protein; N-terminus: TMH(LipoP); 1 transmembrane domain; Metallo-dependent phosphatases (SSF56300); Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (SM00156); Undefined Gene3D domain (G3DSA:3.60.21.10); Metallophosphoesterase (PF00149); Protein involved in hydrolase activity.
  
 0.902
AEK24526.1
AltName: Full=Ap4A hydrolase;AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase;Short=Diadenosine tetraphosphatase; Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (PTHR11668); PROTEIN PHOSPHATASE, CAEEL (PTHR11668:SF16); Metallo-dependent phosphatases (SSF56300); Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (PR00114); Undefined Gene3D domain (G3DSA:3.60.21.10); Metallophosphoesterase (PF00149); Protein involved in hydrolase activity.
  
 0.902
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.899
topA
Swivelase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Fi [...]
  
 0.833
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.753
AEK24381.1
Hypothetical protein; N-terminus: SpI(SignalPHMM); 1 transmembrane domain.
       0.639
AEK22190.1
Hypothetical protein; Weak similarity to UniProt:O34748; Undefined Gene3D domain (G3DSA:3.40.50.300); P-loop containing nucleoside triphosphate hydrolases (SSF52540); DNA/RNA helicase, C-terminal (PF00271); DNA HELICASE RECQ (PTHR13710:SF11); DNA/RNA helicase, DEAD/DEAH box type, N-terminal (PF00270); Helicase, superfamily 1/2, ATP-binding domain (PS51192); DEAD-like helicase, N-terminal (SM00487); DNA helicase, ATP-dependent, RecQ type (PTHR13710); DUF559 (PF04480); DNA/RNA helicase, C-terminal (PS51194); DNA/RNA helicase, C-terminal (SM00490); Protein involved in ATP-dependent helica [...]
  
 0.636
AEK23201.1
ATP-dependent DNA helicase recQ; P-loop containing nucleoside triphosphate hydrolases (SSF52540); Undefined Gene3D domain (G3DSA:3.40.50.300); DNA helicase, ATP-dependent, RecQ type, N-terminal (TIGR00614); Helicase, superfamily 1/2, ATP-binding domain (PS51192); DNA/RNA helicase, DEAD/DEAH box type, N-terminal (PF00270); DNA helicase, ATP-dependent, RecQ type (PTHR13710); DNA/RNA helicase, C-terminal (PS51194); DNA HELICASE RECQ (PTHR13710:SF11); DNA/RNA helicase, C-terminal (PF00271); DEAD-like helicase, N-terminal (SM00487); DNA/RNA helicase, C-terminal (SM00490); Protein involved i [...]
   
 0.629
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
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