STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
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Experiments
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[Homology]
Score
tyrSTyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (431 aa)    
Predicted Functional Partners:
pheT
AltName: Full=Phenylalanine--tRNA ligase beta chain;Short=PheRS; Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding (G3DSA:3.30.70.380); tRNA synthetase, B5 (PF03484); Nucleic acid-binding, OB-fold (G3DSA:2.40.50.140); tRNA synthetase, B5 (G3DSA:3.30.56.20); Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding (SSF54991); B3/B4 tRNA-binding domain (PF03483); Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial (TIGR00472); Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding (PF03147); PHENYLALANYL [...]
  
  
 0.896
metG
Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
 
 0.814
argS
AltName: Full=Arginine--tRNA ligase;Short=ArgRS; Aminoacyl-tRNA synthetase, class I, conserved site (PS00178); Legume lectin, beta chain, Mn/Ca-binding site (PS00307); Arginyl-tRNA synthetase, class Ic (MF_00123); Arginyl-tRNA synthetase, class Ic (TIGR00456); Undefined Gene3D domain (G3DSA:1.10.730.10); Arginyl-tRNA synthetase, class Ic, core (PR01038); Rossmann-like alpha/beta/alpha sandwich fold (G3DSA:3.40.50.620); Arginyl tRNA synthetase, class Ic, N-terminal (PF03485); Arginyl-tRNA synthetase, class Ic, core (PF00750); Aminoacyl-tRNA synthetase, class 1a, anticodon-binding (SSF47 [...]
 
  
 0.758
glyQS
Glycine--tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family.
 
  
 0.664
tsf
Elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.
 
 
 0.655
ileS
Isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
  
 0.637
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
 
  
 0.633
pheS
AltName: Full=Phenylalanine--tRNA ligase alpha chain;Short=PheRS; SYFA_MF_00281 (MF_00281); Phenylalanyl-tRNA synthetase, class IIc, alpha subunit (TIGR00468); tRNA-binding arm (SSF46589); Phenylalanyl-tRNA synthetase, class II, N-terminal (PF02912); Undefined Gene3D domain (G3DSA:3.30.930.10); Class II aaRS and biotin synthetases (SSF55681); Phenylalanyl-tRNA synthetase alpha chain (PF01409); Phenylalanyl-tRNA synthetase alpha chain (PTHR11538); Aminoacyl-tRNA synthetase, class II, conserved domain (PS50862); Protein involved in nucleotide binding, tRNA binding, phenylalanine-tRNA lig [...]
  
  
 0.621
alaS
Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
 
 
 0.583
AEK24497.1
Putative aga operon transcriptional repressor; NagB/RpiA/CoA transferase-like (SSF100950); HTH transcriptional regulator, DeoR N-terminal (PS51000); HTH transcriptional regulator, DeoR N-terminal (PF08220); HTH transcriptional regulator, DeoR N-terminal (PR00037); HTH transcriptional regulator, DeoR (PF00455); HTH transcriptional regulator, DeoR N-terminal (SM00420); Winged helix DNA-binding domain (SSF46785); Transcription regulator, HTH DeoR-type, conserved site (PS00894); Protein involved in transcription factor activity and regulation of transcription, DNA-dependent.
       0.574
Your Current Organism:
Capnocytophaga canimorsus
NCBI taxonomy Id: 860228
Other names: C. canimorsus Cc5, Capnocytophaga canimorsus Cc5, Capnocytophaga canimorsus str. Cc5, Capnocytophaga canimorsus strain Cc5
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