thrc protein (Cladophialophora carrionii) - STRING interaction network

Nodes:

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

thrc

Threonine synthase. (562 aa)

Predicted Functional Partners:

THR1-2

0.999

CLCR_02509

0.994

HOM3

0.972

ILV1

0.941

SER1

0.930

srr

0.917

SDL1

0.912

CLCR_08510

0.912

TOXG

0.909

ILV6

0.890

Your Current Organism:

Cladophialophora carrionii

NCBI taxonomy Id: 86049
Other names: C. carrionii, CBS 160.54, Cladosporium carrionii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLCR_02509	CLCR_08510	A0A1C1CEQ5	A0A1C1CT46	Homoserine dehydrogenase.	Phosphoserine phosphatase.	0.915
CLCR_02509	HOM3	A0A1C1CEQ5	A0A1C1D2D2	Homoserine dehydrogenase.	Aspartokinase.	0.996
CLCR_02509	ILV1	A0A1C1CEQ5	A0A1C1D0K4	Homoserine dehydrogenase.	Threonine dehydratase.	0.819
CLCR_02509	ILV6	A0A1C1CEQ5	A0A1C1D1R0	Homoserine dehydrogenase.	Acetolactate synthase small subunit, mitochondrial.	0.986
CLCR_02509	SDL1	A0A1C1CEQ5	A0A1C1CI86	Homoserine dehydrogenase.	L-serine dehydratase.	0.888
CLCR_02509	SER1	A0A1C1CEQ5	A0A1C1D2C2	Homoserine dehydrogenase.	Phosphoserine aminotransferase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.	0.689
CLCR_02509	THR1-2	A0A1C1CEQ5	A0A1C1D1X2	Homoserine dehydrogenase.	Homoserine kinase.	0.994
CLCR_02509	TOXG	A0A1C1CEQ5	A0A1C1CL06	Homoserine dehydrogenase.	Alanine racemase TOXG.	0.410
CLCR_02509	srr	A0A1C1CEQ5	A0A1C1CHB5	Homoserine dehydrogenase.	Putative serine racemase.	0.739
CLCR_02509	thrc	A0A1C1CEQ5	A0A1C1C8M0	Homoserine dehydrogenase.	Threonine synthase.	0.994
CLCR_08510	CLCR_02509	A0A1C1CT46	A0A1C1CEQ5	Phosphoserine phosphatase.	Homoserine dehydrogenase.	0.915
CLCR_08510	HOM3	A0A1C1CT46	A0A1C1D2D2	Phosphoserine phosphatase.	Aspartokinase.	0.888
CLCR_08510	ILV1	A0A1C1CT46	A0A1C1D0K4	Phosphoserine phosphatase.	Threonine dehydratase.	0.840
CLCR_08510	ILV6	A0A1C1CT46	A0A1C1D1R0	Phosphoserine phosphatase.	Acetolactate synthase small subunit, mitochondrial.	0.814
CLCR_08510	SDL1	A0A1C1CT46	A0A1C1CI86	Phosphoserine phosphatase.	L-serine dehydratase.	0.825
CLCR_08510	SER1	A0A1C1CT46	A0A1C1D2C2	Phosphoserine phosphatase.	Phosphoserine aminotransferase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.	0.949
CLCR_08510	THR1-2	A0A1C1CT46	A0A1C1D1X2	Phosphoserine phosphatase.	Homoserine kinase.	0.904
CLCR_08510	TOXG	A0A1C1CT46	A0A1C1CL06	Phosphoserine phosphatase.	Alanine racemase TOXG.	0.868
CLCR_08510	srr	A0A1C1CT46	A0A1C1CHB5	Phosphoserine phosphatase.	Putative serine racemase.	0.827
CLCR_08510	thrc	A0A1C1CT46	A0A1C1C8M0	Phosphoserine phosphatase.	Threonine synthase.	0.912

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.901

expected number of edges:

11

PPI enrichment p-value:

0.000451

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006289

Nucleotide-excision repair

3 of 5

2.28

1.79

0.00041

GO:0033554

Cellular response to stress

6 of 78

1.39

1.47

8.68e-05

GO:0006281

DNA repair

5 of 54

1.47

1.43

0.00026

GO:0009432

SOS response

3 of 15

1.8

1.22

0.0034

GO:0006308

DNA catabolic process

2 of 5

2.1

1.01

0.0128

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004536

Deoxyribonuclease activity

4 of 23

1.74

1.5

0.00063

GO:0008855

Exodeoxyribonuclease VII activity

2 of 2

2.5

1.16

0.0076

GO:0009381

Excinuclease ABC activity

2 of 3

2.33

1.11

0.0090

GO:0140097

Catalytic activity, acting on DNA

5 of 105

1.18

0.88

0.0039

GO:0140640

Catalytic activity, acting on a nucleic acid

6 of 242

0.9

0.63

0.0071

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009318

Exodeoxyribonuclease VII complex

2 of 2

2.5

1.32

0.0037

GO:0009380

Excinuclease repair complex

2 of 3

2.33

1.28

0.0041

GO:1902494

Catalytic complex

5 of 80

1.3

1.21

0.00043

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:617

DNA damage, and UvrD/REP helicase N-terminal domain

3 of 21

1.66

0.72

0.0372

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tor03420

Nucleotide excision repair

3 of 9

2.03

1.66

0.00053

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990391

DNA repair complex

3 of 6

2.2

1.69

0.00058

GOCC:0009318

Exodeoxyribonuclease VII complex

2 of 2

2.5

1.14

0.0081

GOCC:0009380

Excinuclease repair complex

2 of 3

2.33

1.11

0.0090

GOCC:1902494

Catalytic complex

5 of 192

0.92

0.6

0.0141

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0234

DNA repair

5 of 29

1.74

2.22

6.15e-06

KW-0742

SOS response

3 of 10

1.98

1.67

0.00047

KW-0267

Excision nuclease

2 of 3

2.33

1.24

0.0049

KW-0228

DNA excision

2 of 3

2.33

1.24

0.0049

KW-0269

Exonuclease

2 of 15

1.63

0.74

0.0341

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02151

UvrB/uvrC motif

2 of 2

2.5

0.84

0.0295

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00278

Helix-hairpin-helix DNA-binding motif class 1

2 of 8

1.9

0.7

0.0465

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