CLCR_01428 protein (Cladophialophora carrionii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

CLCR_01428

HET domain-containing protein. (830 aa)

Predicted Functional Partners:

CLCR_05340

0.667

CLCR_01389

0.563

sconC

0.480

rpn11

0.451

CLCR_06724

0.437

CLCR_01234

0.433

hus5

0.420

CLCR_05489

0.419

CLCR_03805

0.419

CLCR_04261

0.417

Your Current Organism:

Cladophialophora carrionii

NCBI taxonomy Id: 86049
Other names: C. carrionii, CBS 160.54, Cladosporium carrionii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLCR_01234	CLCR_01389	A0A1C1CCS1	A0A1C1CAX9	Vacuolar membrane protein.	ANK_REP_REGION domain-containing protein.	0.818
CLCR_01234	CLCR_01428	A0A1C1CCS1	A0A1C1CBK4	Vacuolar membrane protein.	HET domain-containing protein.	0.433
CLCR_01234	CLCR_05489	A0A1C1CCS1	A0A1C1C899	Vacuolar membrane protein.	Putative MHYT domain signaling protein.	0.823
CLCR_01234	CLCR_06724	A0A1C1CCS1	A0A1C1CPE2	Vacuolar membrane protein.	Uncharacterized protein.	0.541
CLCR_01234	sconC	A0A1C1CCS1	A0A1C1CPZ9	Vacuolar membrane protein.	E3 ubiquitin ligase complex SCF subunit sconC; Belongs to the SKP1 family.	0.541
CLCR_01389	CLCR_01234	A0A1C1CAX9	A0A1C1CCS1	ANK_REP_REGION domain-containing protein.	Vacuolar membrane protein.	0.818
CLCR_01389	CLCR_01428	A0A1C1CAX9	A0A1C1CBK4	ANK_REP_REGION domain-containing protein.	HET domain-containing protein.	0.563
CLCR_01389	CLCR_04261	A0A1C1CAX9	A0A1C1CIU0	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.416
CLCR_01389	CLCR_06724	A0A1C1CAX9	A0A1C1CPE2	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.419
CLCR_01389	hus5	A0A1C1CAX9	A0A1C1CU53	ANK_REP_REGION domain-containing protein.	SUMO-conjugating enzyme ubc9; Belongs to the ubiquitin-conjugating enzyme family.	0.741
CLCR_01389	rpn11	A0A1C1CAX9	A0A1C1C704	ANK_REP_REGION domain-containing protein.	26S proteasome regulatory subunit rpn11.	0.434
CLCR_01389	sconC	A0A1C1CAX9	A0A1C1CPZ9	ANK_REP_REGION domain-containing protein.	E3 ubiquitin ligase complex SCF subunit sconC; Belongs to the SKP1 family.	0.419
CLCR_01428	CLCR_01234	A0A1C1CBK4	A0A1C1CCS1	HET domain-containing protein.	Vacuolar membrane protein.	0.433
CLCR_01428	CLCR_01389	A0A1C1CBK4	A0A1C1CAX9	HET domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.563
CLCR_01428	CLCR_03805	A0A1C1CBK4	A0A1C1CJ40	HET domain-containing protein.	Uncharacterized protein.	0.419
CLCR_01428	CLCR_04261	A0A1C1CBK4	A0A1C1CIU0	HET domain-containing protein.	Uncharacterized protein.	0.417
CLCR_01428	CLCR_05340	A0A1C1CBK4	A0A1C1C8X4	HET domain-containing protein.	Sister chromatid cohesion protein.	0.667
CLCR_01428	CLCR_05489	A0A1C1CBK4	A0A1C1C899	HET domain-containing protein.	Putative MHYT domain signaling protein.	0.419
CLCR_01428	CLCR_06724	A0A1C1CBK4	A0A1C1CPE2	HET domain-containing protein.	Uncharacterized protein.	0.437
CLCR_01428	hus5	A0A1C1CBK4	A0A1C1CU53	HET domain-containing protein.	SUMO-conjugating enzyme ubc9; Belongs to the ubiquitin-conjugating enzyme family.	0.420

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

1.95e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 113

1.53

3.27

3.50e-14

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 55

1.8

4.56

7.74e-15

GO:0019843

rRNA binding

9 of 45

1.84

4.47

1.46e-13

GO:0000049

tRNA binding

3 of 30

1.54

0.91

0.0118

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 60

1.77

4.46

3.02e-15

GO:0005622

Intracellular anatomical structure

11 of 1415

0.43

0.37

0.00040

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37185344

(2023) Independent origins and evolution of the secondary replicons of the class Gammaproteobacteria.

6 of 32

1.82

2.93

7.50e-08

PMID:28083017

(2016) Distribution of Hydrogenases in Cyanobacteria: A Phylum-Wide Genomic Survey.

5 of 19

1.96

2.92

3.74e-07

PMID:32209634

(2020) Autogenous regulation in vivo of the rpmE gene encoding ribosomal protein L31 (bL31), a key component of the protein-protein intersubunit bridge B1b.

3 of 13

1.91

1.52

0.00088

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:136

Ribosome

10 of 55

1.8

4.66

2.15e-15

CL:121

Ribosome, and Regulation of translation

11 of 78

1.69

4.24

4.49e-16

CL:141

Ribosome

6 of 33

1.8

3.07

2.09e-08

CL:142

rRNA-binding, and Peptide binding

5 of 23

1.88

2.82

3.52e-07

CL:145

rRNA-binding

3 of 10

2.02

1.8

0.00026

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

amg03010

Ribosome

10 of 53

1.82

4.82

7.78e-16

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

10 of 51

1.84

4.83

1.62e-15

GOCC:0022626

Cytosolic ribosome

6 of 27

1.89

3.35

8.92e-09

GOCC:0044391

Ribosomal subunit

6 of 31

1.83

3.17

1.49e-08

GOCC:0022627

Cytosolic small ribosomal subunit

3 of 11

1.98

1.81

0.00022

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 16

1.82

1.58

0.00049

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 56

1.8

4.61

2.71e-15

KW-0699

rRNA-binding

8 of 39

1.86

4.2

3.27e-12

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