ppk34 protein (Cladophialophora carrionii) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

ppk34

Serine/threonine-protein kinase ppk34; Belongs to the protein kinase superfamily. (449 aa)

Predicted Functional Partners:

CLCR_09562

0.901

CLCR_04993

0.895

CLCR_07915

0.878

SNF4

0.875

CLCR_10006

0.809

CLCR_03690

0.794

sds23

0.726

CLCR_00694

0.721

CLCR_00778

0.679

CBSCBSPB3

0.675

Your Current Organism:

Cladophialophora carrionii

NCBI taxonomy Id: 86049
Other names: C. carrionii, CBS 160.54, Cladosporium carrionii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBSCBSPB3	CLCR_00694	A0A1C1CC17	A0A1C1C6P3	CBS domain-containing protein CBSCBSPB3.	AMPK1_CBM domain-containing protein.	0.915
CBSCBSPB3	CLCR_00778	A0A1C1CC17	A0A1C1D0H7	CBS domain-containing protein CBSCBSPB3.	OSK2 protein.	0.651
CBSCBSPB3	CLCR_03690	A0A1C1CC17	A0A1C1CH21	CBS domain-containing protein CBSCBSPB3.	Uncharacterized protein.	0.651
CBSCBSPB3	CLCR_04993	A0A1C1CC17	A0A1C1CJX2	CBS domain-containing protein CBSCBSPB3.	Uncharacterized protein.	0.675
CBSCBSPB3	CLCR_07915	A0A1C1CC17	A0A1C1CUK2	CBS domain-containing protein CBSCBSPB3.	Kinase domain containing protein.	0.675
CBSCBSPB3	CLCR_09562	A0A1C1CC17	A0A1C1CWY0	CBS domain-containing protein CBSCBSPB3.	Non-specific serine/threonine protein kinase.	0.651
CBSCBSPB3	CLCR_10006	A0A1C1CC17	A0A1C1D020	CBS domain-containing protein CBSCBSPB3.	Snf1 kinase complex beta-subunit Gal83.	0.915
CBSCBSPB3	ppk34	A0A1C1CC17	A0A1C1CJX1	CBS domain-containing protein CBSCBSPB3.	Serine/threonine-protein kinase ppk34; Belongs to the protein kinase superfamily.	0.675
CLCR_00694	CBSCBSPB3	A0A1C1C6P3	A0A1C1CC17	AMPK1_CBM domain-containing protein.	CBS domain-containing protein CBSCBSPB3.	0.915
CLCR_00694	CLCR_00778	A0A1C1C6P3	A0A1C1D0H7	AMPK1_CBM domain-containing protein.	OSK2 protein.	0.685
CLCR_00694	CLCR_03690	A0A1C1C6P3	A0A1C1CH21	AMPK1_CBM domain-containing protein.	Uncharacterized protein.	0.685
CLCR_00694	CLCR_04993	A0A1C1C6P3	A0A1C1CJX2	AMPK1_CBM domain-containing protein.	Uncharacterized protein.	0.721
CLCR_00694	CLCR_07915	A0A1C1C6P3	A0A1C1CUK2	AMPK1_CBM domain-containing protein.	Kinase domain containing protein.	0.721
CLCR_00694	CLCR_09562	A0A1C1C6P3	A0A1C1CWY0	AMPK1_CBM domain-containing protein.	Non-specific serine/threonine protein kinase.	0.685
CLCR_00694	SNF4	A0A1C1C6P3	A0A1C1C9G1	AMPK1_CBM domain-containing protein.	Nuclear protein SNF4.	0.935
CLCR_00694	ppk34	A0A1C1C6P3	A0A1C1CJX1	AMPK1_CBM domain-containing protein.	Serine/threonine-protein kinase ppk34; Belongs to the protein kinase superfamily.	0.721
CLCR_00694	sds23	A0A1C1C6P3	A0A1C1C6D0	AMPK1_CBM domain-containing protein.	Protein sds23.	0.935
CLCR_00778	CBSCBSPB3	A0A1C1D0H7	A0A1C1CC17	OSK2 protein.	CBS domain-containing protein CBSCBSPB3.	0.651
CLCR_00778	CLCR_00694	A0A1C1D0H7	A0A1C1C6P3	OSK2 protein.	AMPK1_CBM domain-containing protein.	0.685
CLCR_00778	CLCR_04993	A0A1C1D0H7	A0A1C1CJX2	OSK2 protein.	Uncharacterized protein.	0.604

page 1 of 5

Network Stats

number of nodes:

9

number of edges:

21

average node degree:

4.67

avg. local clustering coefficient:

0.833

expected number of edges:

8

PPI enrichment p-value:

0.000108

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006352

DNA-templated transcription, initiation

7 of 50

1.85

3.63

1.33e-09

GO:0050896

Response to stimulus

7 of 444

0.9

0.84

9.93e-05

GO:0043170

Macromolecule metabolic process

8 of 857

0.67

0.56

0.00040

GO:0006807

Nitrogen compound metabolic process

8 of 1210

0.52

0.39

0.0048

GO:0044238

Primary metabolic process

8 of 1442

0.45

0.32

0.0179

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016987

Sigma factor activity

7 of 50

1.85

3.7

7.11e-10

GO:0003677

DNA binding

7 of 301

1.07

1.12

2.96e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8468

RNA polymerase sigma factor 70, region 4 type 2

5 of 11

2.36

4.26

8.75e-09

CL:8466

RNA polymerase sigma factor 70, region 4 type 2, and Bacterial repeat domain

6 of 23

2.12

4.09

3.27e-09

CL:8471

RNA polymerase sigma-70, Bacteroidetes type, and RNA polymerase sigma factor 70, region 4 type 2

2 of 5

2.31

1.17

0.0093

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

7 of 72

1.69

3.1

3.20e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0731

Sigma factor

7 of 41

1.94

4.23

6.97e-11

KW-0238

DNA-binding

7 of 164

1.33

1.88

1.69e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04542

Sigma-70 region 2

7 of 37

1.98

4.31

1.02e-10

PF08281

Sigma-70, region 4

4 of 30

1.83

1.97

9.55e-05

PF04545

Sigma-70, region 4

3 of 14

2.03

1.69

0.00072

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013249

RNA polymerase sigma factor 70, region 4 type 2

7 of 33

2.03

4.41

1.27e-10

IPR039425

RNA polymerase sigma-70 like

7 of 37

1.98

4.27

1.30e-10

IPR007627

RNA polymerase sigma-70 region 2

7 of 37

1.98

4.27

1.30e-10

IPR013325

RNA polymerase sigma factor, region 2

7 of 41

1.94

4.15

1.30e-10

IPR014284

RNA polymerase sigma-70 like domain

7 of 47

1.88

3.91

2.40e-10

(more ...)

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