eef1b protein (Cladophialophora carrionii) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

eef1b

Elongation factor 1-beta; Belongs to the EF-1-beta/EF-1-delta family. (228 aa)

Predicted Functional Partners:

TEF4

0.999

TEF1

0.996

CLCR_07561

0.980

CLCR_01230

0.970

rps20

0.970

RPL35

0.967

crpp0

0.964

rps1

0.963

rps3

0.956

CLCR_00214

0.956

Your Current Organism:

Cladophialophora carrionii

NCBI taxonomy Id: 86049
Other names: C. carrionii, CBS 160.54, Cladosporium carrionii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLCR_00214	CLCR_01230	A0A1C1CZY2	A0A1C1CD68	60S acidic ribosomal protein P2; Belongs to the eukaryotic ribosomal protein P1/P2 family.	Guanine nucleotide-binding protein subunit beta-like protein.	0.994
CLCR_00214	CLCR_07561	A0A1C1CZY2	A0A1C1CMV8	60S acidic ribosomal protein P2; Belongs to the eukaryotic ribosomal protein P1/P2 family.	Translationally-controlled tumor protein like protein; Belongs to the TCTP family.	0.932
CLCR_00214	RPL35	A0A1C1CZY2	A0A1C1CT70	60S acidic ribosomal protein P2; Belongs to the eukaryotic ribosomal protein P1/P2 family.	60S ribosomal protein L35.	0.998
CLCR_00214	TEF1	A0A1C1CZY2	A0A1C1C6C1	60S acidic ribosomal protein P2; Belongs to the eukaryotic ribosomal protein P1/P2 family.	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	0.470
CLCR_00214	TEF4	A0A1C1CZY2	A0A1C1D1T4	60S acidic ribosomal protein P2; Belongs to the eukaryotic ribosomal protein P1/P2 family.	Elongation factor 1-gamma 2.	0.902
CLCR_00214	crpp0	A0A1C1CZY2	A0A1C1CI82	60S acidic ribosomal protein P2; Belongs to the eukaryotic ribosomal protein P1/P2 family.	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10.	0.999
CLCR_00214	eef1b	A0A1C1CZY2	A0A1C1CTQ8	60S acidic ribosomal protein P2; Belongs to the eukaryotic ribosomal protein P1/P2 family.	Elongation factor 1-beta; Belongs to the EF-1-beta/EF-1-delta family.	0.956
CLCR_00214	rps1	A0A1C1CZY2	A0A1C1D257	60S acidic ribosomal protein P2; Belongs to the eukaryotic ribosomal protein P1/P2 family.	40S ribosomal protein S1; Belongs to the eukaryotic ribosomal protein eS1 family.	0.995
CLCR_00214	rps20	A0A1C1CZY2	A0A1C1CHD3	60S acidic ribosomal protein P2; Belongs to the eukaryotic ribosomal protein P1/P2 family.	40S ribosomal protein S20.	0.996
CLCR_00214	rps3	A0A1C1CZY2	A0A1C1CBL8	60S acidic ribosomal protein P2; Belongs to the eukaryotic ribosomal protein P1/P2 family.	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.996
CLCR_01230	CLCR_00214	A0A1C1CD68	A0A1C1CZY2	Guanine nucleotide-binding protein subunit beta-like protein.	60S acidic ribosomal protein P2; Belongs to the eukaryotic ribosomal protein P1/P2 family.	0.994
CLCR_01230	CLCR_07561	A0A1C1CD68	A0A1C1CMV8	Guanine nucleotide-binding protein subunit beta-like protein.	Translationally-controlled tumor protein like protein; Belongs to the TCTP family.	0.958
CLCR_01230	RPL35	A0A1C1CD68	A0A1C1CT70	Guanine nucleotide-binding protein subunit beta-like protein.	60S ribosomal protein L35.	0.998
CLCR_01230	TEF1	A0A1C1CD68	A0A1C1C6C1	Guanine nucleotide-binding protein subunit beta-like protein.	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	0.959
CLCR_01230	TEF4	A0A1C1CD68	A0A1C1D1T4	Guanine nucleotide-binding protein subunit beta-like protein.	Elongation factor 1-gamma 2.	0.974
CLCR_01230	crpp0	A0A1C1CD68	A0A1C1CI82	Guanine nucleotide-binding protein subunit beta-like protein.	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10.	0.999
CLCR_01230	eef1b	A0A1C1CD68	A0A1C1CTQ8	Guanine nucleotide-binding protein subunit beta-like protein.	Elongation factor 1-beta; Belongs to the EF-1-beta/EF-1-delta family.	0.970
CLCR_01230	rps1	A0A1C1CD68	A0A1C1D257	Guanine nucleotide-binding protein subunit beta-like protein.	40S ribosomal protein S1; Belongs to the eukaryotic ribosomal protein eS1 family.	0.998
CLCR_01230	rps20	A0A1C1CD68	A0A1C1CHD3	Guanine nucleotide-binding protein subunit beta-like protein.	40S ribosomal protein S20.	0.999
CLCR_01230	rps3	A0A1C1CD68	A0A1C1CBL8	Guanine nucleotide-binding protein subunit beta-like protein.	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.999

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.761

expected number of edges:

12

PPI enrichment p-value:

9.59e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018105

Peptidyl-serine phosphorylation

3 of 90

1.9

1.1

0.0072

GO:0071218

Cellular response to misfolded protein

2 of 19

2.4

0.99

0.0155

GO:0051247

Positive regulation of protein metabolic process

3 of 135

1.73

0.96

0.0118

GO:0006515

Protein quality control for misfolded or incompletely synthesized proteins

2 of 43

2.05

0.73

0.0434

GO:0045862

Positive regulation of proteolysis

2 of 57

1.93

0.71

0.0450

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004842

Ubiquitin-protein transferase activity

4 of 422

1.36

0.82

0.0137

GO:0061630

Ubiquitin protein ligase activity

3 of 225

1.51

0.74

0.0291

GO:0140096

Catalytic activity, acting on a protein

9 of 3324

0.81

0.69

0.00053

GO:0016740

Transferase activity

10 of 4634

0.71

0.6

0.00053

GO:0016301

Kinase activity

6 of 1874

0.89

0.56

0.0178

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005776

Autophagosome

2 of 22

2.34

0.79

0.0353

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13820

Mixed, incl. Ubiquitin conjugating enzyme activity, and Ubiquitin homologues

3 of 84

1.93

0.83

0.0263

CL:20418

Mixed, incl. MAP kinase activity, and Rho (Ras homology) subfamily of Ras-like small GTPases

2 of 21

2.36

0.82

0.0312

CL:35943

Autophagy - other

2 of 23

2.32

0.82

0.0317

CL:13925

Ubiquitin conjugating enzyme activity, and Lipid desaturase domain

2 of 27

2.25

0.78

0.0375

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005776

Autophagosome

2 of 17

2.45

0.81

0.0341

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045202

CHIP , U-box domain

2 of 2

3.38

1.25

0.0056

IPR045200

E3 ubiquitin-protein ligase CHIP

2 of 2

3.38

1.25

0.0056

IPR000433

Zinc finger, ZZ-type

2 of 8

2.78

1.03

0.0139

IPR043145

Zinc finger, ZZ-type superfamily

2 of 9

2.73

1.02

0.0139

IPR027370

Zinc finger, RING-type, eukaryotic

2 of 12

2.6

0.98

0.0168

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00028

Tetratricopeptide repeats

3 of 67

2.03

1.47

0.0014

SM00291

Zinc-binding domain, present in Dystrophin, CREB-binding protein.

2 of 15

2.51

1.25

0.0052

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