node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFT37137.1 | SFT37861.1 | SAMN04515657_0139 | SAMN04515657_0185 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
SFT37137.1 | SFT40262.1 | SAMN04515657_0139 | SAMN04515657_0330 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | 0.647 |
SFT37137.1 | SFT43722.1 | SAMN04515657_0139 | SAMN04515657_0522 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 4-amino-4-deoxychorismate lyase. | 0.577 |
SFT37137.1 | SFT61816.1 | SAMN04515657_0139 | SAMN04515657_1417 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | 0.827 |
SFT37137.1 | SFT79137.1 | SAMN04515657_0139 | SAMN04515657_2203 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.833 |
SFT37137.1 | SFT79158.1 | SAMN04515657_0139 | SAMN04515657_2204 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | 0.720 |
SFT37137.1 | glyA | SAMN04515657_0139 | SAMN04515657_1087 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.955 |
SFT37861.1 | SFT37137.1 | SAMN04515657_0185 | SAMN04515657_0139 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.997 |
SFT37861.1 | SFT40262.1 | SAMN04515657_0185 | SAMN04515657_0330 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | 0.941 |
SFT37861.1 | SFT43722.1 | SAMN04515657_0185 | SAMN04515657_0522 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 4-amino-4-deoxychorismate lyase. | 0.930 |
SFT37861.1 | SFT50576.1 | SAMN04515657_0185 | SAMN04515657_0913 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Aminodeoxychorismate synthase, subunit I. | 0.726 |
SFT37861.1 | SFT61816.1 | SAMN04515657_0185 | SAMN04515657_1417 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | 0.999 |
SFT37861.1 | SFT79137.1 | SAMN04515657_0185 | SAMN04515657_2203 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.993 |
SFT37861.1 | SFT79158.1 | SAMN04515657_0185 | SAMN04515657_2204 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | 0.991 |
SFT37861.1 | SFT83169.1 | SAMN04515657_0185 | SAMN04515657_2321 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Aspartate kinase /homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.734 |
SFT37861.1 | glmM | SAMN04515657_0185 | SAMN04515657_0186 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.923 |
SFT37861.1 | glyA | SAMN04515657_0185 | SAMN04515657_1087 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.744 |
SFT40262.1 | SFT37137.1 | SAMN04515657_0330 | SAMN04515657_0139 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.647 |
SFT40262.1 | SFT37861.1 | SAMN04515657_0330 | SAMN04515657_0185 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.941 |
SFT40262.1 | SFT79137.1 | SAMN04515657_0330 | SAMN04515657_2203 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.969 |