node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KIE04296.1 | KIE05504.1 | NF27_IN00370 | NF27_DP00480 | Putative glutamate--cysteine ligase; Product derived from UniProtKB/Trembl:I3TPH1. | Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.961 |
KIE04296.1 | ffh_2 | NF27_IN00370 | NF27_CG01090 | Putative glutamate--cysteine ligase; Product derived from UniProtKB/Trembl:I3TPH1. | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] | 0.537 |
KIE04296.1 | ftsY_2 | NF27_IN00370 | NF27_HQ00190 | Putative glutamate--cysteine ligase; Product derived from UniProtKB/Trembl:I3TPH1. | Signal recognition particle receptor FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. | 0.528 |
KIE04296.1 | secB_2 | NF27_IN00370 | NF27_DP00530 | Putative glutamate--cysteine ligase; Product derived from UniProtKB/Trembl:I3TPH1. | Protein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. | 0.528 |
KIE04296.1 | secE | NF27_IN00370 | NF27_DP00030 | Putative glutamate--cysteine ligase; Product derived from UniProtKB/Trembl:I3TPH1. | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.959 |
KIE04296.1 | secF_2 | NF27_IN00370 | NF27_DP00590 | Putative glutamate--cysteine ligase; Product derived from UniProtKB/Trembl:I3TPH1. | Protein translocase subunit SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.993 |
KIE04296.1 | secY_2 | NF27_IN00370 | NF27_CG00230 | Putative glutamate--cysteine ligase; Product derived from UniProtKB/Trembl:I3TPH1. | Protein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.960 |
KIE04296.1 | yajC_2 | NF27_IN00370 | NF27_HQ00320 | Putative glutamate--cysteine ligase; Product derived from UniProtKB/Trembl:I3TPH1. | Immunogenic membrane protein YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.860 |
KIE04296.1 | yidC_2 | NF27_IN00370 | NF27_BK00400 | Putative glutamate--cysteine ligase; Product derived from UniProtKB/Trembl:I3TPH1. | Membrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.973 |
KIE05504.1 | KIE04296.1 | NF27_DP00480 | NF27_IN00370 | Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Putative glutamate--cysteine ligase; Product derived from UniProtKB/Trembl:I3TPH1. | 0.961 |
KIE05504.1 | ffh_2 | NF27_DP00480 | NF27_CG01090 | Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] | 0.971 |
KIE05504.1 | ftsY_2 | NF27_DP00480 | NF27_HQ00190 | Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Signal recognition particle receptor FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. | 0.972 |
KIE05504.1 | secB_2 | NF27_DP00480 | NF27_DP00530 | Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Protein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. | 0.784 |
KIE05504.1 | secD_2 | NF27_DP00480 | NF27_DT00910 | Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Protein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.987 |
KIE05504.1 | secE | NF27_DP00480 | NF27_DP00030 | Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.998 |
KIE05504.1 | secF_2 | NF27_DP00480 | NF27_DP00590 | Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Protein translocase subunit SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.980 |
KIE05504.1 | secY_2 | NF27_DP00480 | NF27_CG00230 | Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Protein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.995 |
KIE05504.1 | yajC_2 | NF27_DP00480 | NF27_HQ00320 | Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Immunogenic membrane protein YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.858 |
KIE05504.1 | yidC_2 | NF27_DP00480 | NF27_BK00400 | Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Membrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.983 |
ffh_2 | KIE04296.1 | NF27_CG01090 | NF27_IN00370 | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] | Putative glutamate--cysteine ligase; Product derived from UniProtKB/Trembl:I3TPH1. | 0.537 |