KIE05161.1 protein (Jidaibacter acanthamoeba)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

KIE05161.1

Uncharacterized protein; Product derived from UniProtKB/Trembl:K1H4C8. (71 aa)

Predicted Functional Partners:

KIE05160.1

0.801

KIE04381.1

0.789

KIE05162.1

0.773

KIE04663.1

0.743

KIE06269.1

0.723

KIE06272.1

0.723

KIE06194.1

0.723

KIE04790.1

0.723

KIE04658.1

0.723

KIE05956.1

0.709

Your Current Organism:

Jidaibacter acanthamoeba

NCBI taxonomy Id: 86105
Other names: C. Jidaibacter acanthamoeba, Candidatus Jidaibacter acanthamoeba, endosymbiont of Acanthamoeba sp. UWC36

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KIE04381.1	KIE04658.1	NF27_IE00170	NF27_GY00050	Hypothetical protein.	Hypothetical protein.	0.556
KIE04381.1	KIE05160.1	NF27_IE00170	NF27_ER00030	Hypothetical protein.	Hypothetical protein.	0.598
KIE04381.1	KIE05161.1	NF27_IE00170	NF27_ER00040	Hypothetical protein.	Uncharacterized protein; Product derived from UniProtKB/Trembl:K1H4C8.	0.789
KIE04381.1	KIE06269.1	NF27_IE00170	NF27_AK00010	Hypothetical protein.	Hypothetical protein.	0.475
KIE04381.1	KIE06272.1	NF27_IE00170	NF27_AK00040	Hypothetical protein.	Hypothetical protein.	0.558
KIE04658.1	KIE04381.1	NF27_GY00050	NF27_IE00170	Hypothetical protein.	Hypothetical protein.	0.556
KIE04658.1	KIE05161.1	NF27_GY00050	NF27_ER00040	Hypothetical protein.	Uncharacterized protein; Product derived from UniProtKB/Trembl:K1H4C8.	0.723
KIE04658.1	KIE05956.1	NF27_GY00050	NF27_CG01360	Hypothetical protein.	Hypothetical protein.	0.789
KIE04663.1	KIE04790.1	NF27_GW00010	NF27_FW00040	Hypothetical protein.	Hypothetical protein.	0.859
KIE04663.1	KIE05161.1	NF27_GW00010	NF27_ER00040	Hypothetical protein.	Uncharacterized protein; Product derived from UniProtKB/Trembl:K1H4C8.	0.743
KIE04663.1	KIE05956.1	NF27_GW00010	NF27_CG01360	Hypothetical protein.	Hypothetical protein.	0.920
KIE04663.1	KIE06269.1	NF27_GW00010	NF27_AK00010	Hypothetical protein.	Hypothetical protein.	0.859
KIE04790.1	KIE04663.1	NF27_FW00040	NF27_GW00010	Hypothetical protein.	Hypothetical protein.	0.859
KIE04790.1	KIE05161.1	NF27_FW00040	NF27_ER00040	Hypothetical protein.	Uncharacterized protein; Product derived from UniProtKB/Trembl:K1H4C8.	0.723
KIE04790.1	KIE05956.1	NF27_FW00040	NF27_CG01360	Hypothetical protein.	Hypothetical protein.	0.542
KIE05160.1	KIE04381.1	NF27_ER00030	NF27_IE00170	Hypothetical protein.	Hypothetical protein.	0.598
KIE05160.1	KIE05161.1	NF27_ER00030	NF27_ER00040	Hypothetical protein.	Uncharacterized protein; Product derived from UniProtKB/Trembl:K1H4C8.	0.801
KIE05160.1	KIE05162.1	NF27_ER00030	NF27_ER00050	Hypothetical protein.	Hypothetical protein.	0.773
KIE05160.1	KIE05956.1	NF27_ER00030	NF27_CG01360	Hypothetical protein.	Hypothetical protein.	0.428
KIE05161.1	KIE04381.1	NF27_ER00040	NF27_IE00170	Uncharacterized protein; Product derived from UniProtKB/Trembl:K1H4C8.	Hypothetical protein.	0.789

page 1 of 3

Network Stats

number of nodes:

6

number of edges:

14

average node degree:

4.67

avg. local clustering coefficient:

0.933

expected number of edges:

5

PPI enrichment p-value:

0.000638

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005975

Carbohydrate metabolic process

9 of 163

1.16

1.46

4.11e-07

GO:0005980

Glycogen catabolic process

2 of 2

2.42

0.75

0.0435

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004553

Hydrolase activity, hydrolyzing O-glycosyl compounds

7 of 24

1.88

3.57

1.52e-09

GO:0004133

Glycogen debranching enzyme activity

2 of 2

2.42

0.98

0.0160

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1332

Carbohydrate metabolic process, and ROK family

9 of 70

1.53

2.8

1.76e-10

CL:1414

Starch and sucrose metabolism, and Six-hairpin glycosidase-like superfamily

3 of 12

1.82

1.3

0.0023

CL:1455

Fructose and mannose metabolism

2 of 5

2.02

0.85

0.0248

CL:1417

Glycosyl hydrolase, family 13, catalytic domain, and 1,4-alpha-oligoglucan phosphorylase activity

2 of 6

1.94

0.81

0.0289

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ari00500

Starch and sucrose metabolism

9 of 17

2.14

6.28

4.67e-16

ari00460

Cyanoamino acid metabolism

3 of 6

2.12

1.91

0.00018

ari00052

Galactose metabolism

2 of 13

1.61

0.76

0.0289

ari01110

Biosynthesis of secondary metabolites

7 of 283

0.81

0.69

0.00059

ari01100

Metabolic pathways

9 of 546

0.64

0.53

0.00045

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098591

External side of apical plasma membrane

2 of 2

2.42

0.95

0.0184

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0326

Glycosidase

6 of 16

1.99

3.56

7.72e-09

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02922

Carbohydrate-binding module 48 (Isoamylase N-terminal domain)

3 of 3

2.42

1.85

0.00035

PF00128

Alpha amylase, catalytic domain

3 of 3

2.42

1.85

0.00035

PF00232

Glycosyl hydrolase family 1

2 of 2

2.42

1.06

0.0114

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017853

Glycoside hydrolase superfamily

8 of 18

2.07

4.89

2.44e-12

IPR006047

Glycosyl hydrolase, family 13, catalytic domain

4 of 5

2.32

2.63

8.27e-06

IPR013780

Glycosyl hydrolase, all-beta

4 of 6

2.24

2.57

9.17e-06

IPR004193

Glycoside hydrolase, family 13, N-terminal

3 of 3

2.42

1.93

0.00024

IPR014756

Immunoglobulin E-set

3 of 6

2.12

1.6

0.00080

(more ...)

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