kpsT_2 protein (Jidaibacter acanthamoeba) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

kpsT_2

Polysialic acid transport ATP-binding protein KpsT; Product derived from UniProtKB/Swiss-Prot:P23888;Gene name derived from UniProtKB/Swiss-Prot:P23888. (220 aa)

Predicted Functional Partners:

KIE05036.1

0.999

KIE05038.1

0.995

KIE04799.1

0.992

lipA_3

0.983

KIE05040.1

0.949

KIE04625.1

0.656

rfbM_2

0.656

KIE05331.1

0.604

KIE05041.1

0.556

KIE05042.1

0.556

Your Current Organism:

Jidaibacter acanthamoeba

NCBI taxonomy Id: 86105
Other names: C. Jidaibacter acanthamoeba, Candidatus Jidaibacter acanthamoeba, endosymbiont of Acanthamoeba sp. UWC36

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KIE04625.1	kpsT_2	NF27_HE00140	NF27_EY01330	Mannose-6-phosphate isomerase/mannose-1-phosphate guanylyl transferase; Product derived from UniProtKB/Trembl:A6DJI0.	Polysialic acid transport ATP-binding protein KpsT; Product derived from UniProtKB/Swiss-Prot:P23888;Gene name derived from UniProtKB/Swiss-Prot:P23888.	0.656
KIE04625.1	rfbM_2	NF27_HE00140	NF27_HE00150	Mannose-6-phosphate isomerase/mannose-1-phosphate guanylyl transferase; Product derived from UniProtKB/Trembl:A6DJI0.	Mannose-1-phosphate guanylyltransferase; Product derived from UniProtKB/Swiss-Prot:Q00473;Gene name derived from UniProtKB/Swiss-Prot:Q00473;EC number derived from UniProtKB/Swiss-Prot:Q00473; Belongs to the mannose-6-phosphate isomerase type 2 family.	0.999
KIE04799.1	KIE05038.1	NF27_FW00130	NF27_EY01340	Hypothetical protein.	Hypothetical protein.	0.917
KIE04799.1	kpsT_2	NF27_FW00130	NF27_EY01330	Hypothetical protein.	Polysialic acid transport ATP-binding protein KpsT; Product derived from UniProtKB/Swiss-Prot:P23888;Gene name derived from UniProtKB/Swiss-Prot:P23888.	0.992
KIE04799.1	lipA_3	NF27_FW00130	NF27_EY01350	Hypothetical protein.	Capsule polysaccharide modification protein LipA; Product derived from UniProtKB/Swiss-Prot:P57037;Gene name derived from UniProtKB/Swiss-Prot:P57037.	0.730
KIE05036.1	KIE05038.1	NF27_EY01320	NF27_EY01340	Hypothetical protein.	Hypothetical protein.	0.995
KIE05036.1	KIE05040.1	NF27_EY01320	NF27_EY01360	Hypothetical protein.	Hypothetical protein.	0.954
KIE05036.1	KIE05041.1	NF27_EY01320	NF27_EY01370	Hypothetical protein.	Hypothetical protein.	0.556
KIE05036.1	KIE05042.1	NF27_EY01320	NF27_EY01380	Hypothetical protein.	Hypothetical protein.	0.556
KIE05036.1	kpsT_2	NF27_EY01320	NF27_EY01330	Hypothetical protein.	Polysialic acid transport ATP-binding protein KpsT; Product derived from UniProtKB/Swiss-Prot:P23888;Gene name derived from UniProtKB/Swiss-Prot:P23888.	0.999
KIE05036.1	lipA_3	NF27_EY01320	NF27_EY01350	Hypothetical protein.	Capsule polysaccharide modification protein LipA; Product derived from UniProtKB/Swiss-Prot:P57037;Gene name derived from UniProtKB/Swiss-Prot:P57037.	0.993
KIE05038.1	KIE04799.1	NF27_EY01340	NF27_FW00130	Hypothetical protein.	Hypothetical protein.	0.917
KIE05038.1	KIE05036.1	NF27_EY01340	NF27_EY01320	Hypothetical protein.	Hypothetical protein.	0.995
KIE05038.1	KIE05040.1	NF27_EY01340	NF27_EY01360	Hypothetical protein.	Hypothetical protein.	0.956
KIE05038.1	KIE05041.1	NF27_EY01340	NF27_EY01370	Hypothetical protein.	Hypothetical protein.	0.556
KIE05038.1	KIE05042.1	NF27_EY01340	NF27_EY01380	Hypothetical protein.	Hypothetical protein.	0.556
KIE05038.1	kpsT_2	NF27_EY01340	NF27_EY01330	Hypothetical protein.	Polysialic acid transport ATP-binding protein KpsT; Product derived from UniProtKB/Swiss-Prot:P23888;Gene name derived from UniProtKB/Swiss-Prot:P23888.	0.995
KIE05038.1	lipA_3	NF27_EY01340	NF27_EY01350	Hypothetical protein.	Capsule polysaccharide modification protein LipA; Product derived from UniProtKB/Swiss-Prot:P57037;Gene name derived from UniProtKB/Swiss-Prot:P57037.	0.993
KIE05040.1	KIE05036.1	NF27_EY01360	NF27_EY01320	Hypothetical protein.	Hypothetical protein.	0.954
KIE05040.1	KIE05038.1	NF27_EY01360	NF27_EY01340	Hypothetical protein.	Hypothetical protein.	0.956

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.46

expected number of edges:

10

PPI enrichment p-value:

1.13e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006396

RNA processing

6 of 91

1.7

2.37

1.24e-06

GO:0034470

ncRNA processing

5 of 75

1.7

2.06

1.40e-05

GO:0008033

tRNA processing

4 of 56

1.73

1.71

0.00017

GO:0009451

RNA modification

4 of 58

1.72

1.7

0.00017

GO:0006364

rRNA processing

3 of 21

2.03

1.67

0.00050

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

5 of 134

1.45

1.36

0.00040

GO:0140098

Catalytic activity, acting on RNA

5 of 154

1.39

1.3

0.00040

GO:0008649

rRNA methyltransferase activity

2 of 6

2.4

1.18

0.0068

GO:0051539

4 iron, 4 sulfur cluster binding

3 of 43

1.72

1.13

0.0049

GO:0000049

tRNA binding

2 of 25

1.78

0.8

0.0282

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1478

0.71

0.64

5.18e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2315

Mixed, incl. tRNA processing, and NusB family

4 of 21

2.16

2.28

3.19e-05

CL:2316

Mixed, incl. NusB family, and Methylthiotransferase

3 of 12

2.28

1.73

0.00053

CL:1849

Translation, and Ribosome biogenesis

5 of 142

1.42

1.3

0.00053

CL:2073

Mixed, incl. TGS-like, and RF-1 domain

2 of 6

2.4

1.02

0.0137

CL:2110

3-5 exonuclease, and S1 domain

2 of 8

2.28

0.94

0.0183

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

5 of 399

0.98

0.59

0.0210

GOCC:0005737

Cytoplasm

7 of 1152

0.66

0.43

0.0210

GOCC:0005622

Intracellular

9 of 1930

0.55

0.37

0.0210

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0698

rRNA processing

3 of 13

2.24

2.15

7.19e-05

KW-0949

S-adenosyl-L-methionine

4 of 52

1.76

1.89

6.65e-05

KW-0963

Cytoplasm

7 of 238

1.35

1.76

1.20e-06

KW-0819

tRNA processing

3 of 28

1.91

1.65

0.00043

KW-0004

4Fe-4S

3 of 39

1.76

1.46

0.00087

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007197

Radical SAM

3 of 24

1.97

1.06

0.0094

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00729

Elongator protein 3, MiaB family, Radical SAM

3 of 18

2.1

1.78

0.00034

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