KIE04767.1 protein (Jidaibacter acanthamoeba)

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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[Homology]

Score

KIE04767.1

Hypothetical protein. (248 aa)

Predicted Functional Partners:

KIE04768.1

0.952

grxC2_2

0.737

KIE04770.1

0.737

efp_2

0.737

KIE05602.1

0.721

KIE05506.1

0.583

KIE04310.1

0.573

KIE05072.1

0.558

KIE05944.1

0.542

KIE04581.1

0.507

Your Current Organism:

Jidaibacter acanthamoeba

NCBI taxonomy Id: 86105
Other names: C. Jidaibacter acanthamoeba, Candidatus Jidaibacter acanthamoeba, endosymbiont of Acanthamoeba sp. UWC36

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KIE04310.1	KIE04767.1	NF27_IN00510	NF27_FX00280	Hypothetical protein.	Hypothetical protein.	0.573
KIE04310.1	KIE05506.1	NF27_IN00510	NF27_DP00500	Hypothetical protein.	Hypothetical protein.	0.758
KIE04310.1	KIE05602.1	NF27_IN00510	NF27_DP01460	Hypothetical protein.	Hypothetical protein.	0.723
KIE04310.1	KIE05944.1	NF27_IN00510	NF27_CG01240	Hypothetical protein.	Hypothetical protein.	0.764
KIE04581.1	KIE04767.1	NF27_HJ00340	NF27_FX00280	Hypothetical protein; Belongs to the ATPase B chain family.	Hypothetical protein.	0.507
KIE04581.1	KIE05506.1	NF27_HJ00340	NF27_DP00500	Hypothetical protein; Belongs to the ATPase B chain family.	Hypothetical protein.	0.402
KIE04581.1	KIE05602.1	NF27_HJ00340	NF27_DP01460	Hypothetical protein; Belongs to the ATPase B chain family.	Hypothetical protein.	0.603
KIE04767.1	KIE04310.1	NF27_FX00280	NF27_IN00510	Hypothetical protein.	Hypothetical protein.	0.573
KIE04767.1	KIE04581.1	NF27_FX00280	NF27_HJ00340	Hypothetical protein.	Hypothetical protein; Belongs to the ATPase B chain family.	0.507
KIE04767.1	KIE04768.1	NF27_FX00280	NF27_FX00290	Hypothetical protein.	Hypothetical protein.	0.952
KIE04767.1	KIE04770.1	NF27_FX00280	NF27_FX00310	Hypothetical protein.	Uncharacterized protein; Product derived from UniProtKB/Swiss-Prot:P73055; Uncharacterized protein ssr3122; Belongs to the BolA/IbaG family.	0.737
KIE04767.1	KIE05072.1	NF27_FX00280	NF27_EY01680	Hypothetical protein.	Hypothetical protein.	0.558
KIE04767.1	KIE05506.1	NF27_FX00280	NF27_DP00500	Hypothetical protein.	Hypothetical protein.	0.583
KIE04767.1	KIE05602.1	NF27_FX00280	NF27_DP01460	Hypothetical protein.	Hypothetical protein.	0.721
KIE04767.1	KIE05944.1	NF27_FX00280	NF27_CG01240	Hypothetical protein.	Hypothetical protein.	0.542
KIE04767.1	efp_2	NF27_FX00280	NF27_FX00320	Hypothetical protein.	Elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.	0.737
KIE04767.1	grxC2_2	NF27_FX00280	NF27_FX00300	Hypothetical protein.	Putative monothiol glutaredoxin-2; Product derived from UniProtKB/Swiss-Prot:Q92GH5;Gene name derived from UniProtKB/Swiss-Prot:Q92GH5; Belongs to the glutaredoxin family. Monothiol subfamily.	0.737
KIE04768.1	KIE04767.1	NF27_FX00290	NF27_FX00280	Hypothetical protein.	Hypothetical protein.	0.952
KIE04768.1	KIE04770.1	NF27_FX00290	NF27_FX00310	Hypothetical protein.	Uncharacterized protein; Product derived from UniProtKB/Swiss-Prot:P73055; Uncharacterized protein ssr3122; Belongs to the BolA/IbaG family.	0.737
KIE04768.1	efp_2	NF27_FX00290	NF27_FX00320	Hypothetical protein.	Elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.	0.738

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.923

expected number of edges:

12

PPI enrichment p-value:

0.101

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051403

Stress-activated MAPK cascade

4 of 13

2.53

3.18

9.53e-07

GO:0006468

Protein phosphorylation

9 of 297

1.52

2.7

6.35e-10

GO:0051301

Cell division

5 of 132

1.62

1.89

2.46e-05

GO:0071310

Cellular response to organic substance

4 of 87

1.71

1.62

0.00026

GO:0071554

Cell wall organization or biogenesis

4 of 130

1.53

1.28

0.0011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004709

MAP kinase kinase kinase activity

4 of 6

2.87

4.16

1.91e-08

GO:0004674

Protein serine/threonine kinase activity

9 of 249

1.6

3.1

6.11e-11

GO:0005524

ATP binding

9 of 948

1.02

1.16

1.04e-06

GO:1901363

Heterocyclic compound binding

10 of 2877

0.58

0.49

0.00035

GO:0097159

Organic cyclic compound binding

10 of 2896

0.58

0.48

0.00036

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10482

MADS SRF-like, and Hippo signaling pathway - multiple species

6 of 17

2.59

5.49

1.88e-11

CL:10485

MADS SRF-like, and Smooth muscle protein/calponin

5 of 10

2.74

5.04

2.84e-10

CL:4336

Stress-activated MAPK cascade

4 of 11

2.6

3.57

1.79e-07

CL:4338

MAPK1 (ERK2) activation, and MAP kinase kinase kinase activity

2 of 6

2.57

1.35

0.0034

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04392

Hippo signaling pathway - multiple species

5 of 9

2.79

5.41

6.06e-11

map04111

Cell cycle - yeast

6 of 127

1.72

2.79

4.92e-08

map04113

Meiosis - yeast

5 of 148

1.57

1.99

6.23e-06

map04011

MAPK signaling pathway - yeast

5 of 221

1.4

1.58

3.26e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2871796

FCERI mediated MAPK activation

5 of 13

2.63

4.59

1.68e-09

MAP-2454202

Fc epsilon receptor (FCERI) signaling

5 of 34

2.21

3.53

5.60e-08

MAP-168256

Immune System

9 of 798

1.09

1.33

3.69e-07

MAP-168249

Innate Immune System

5 of 517

1.03

0.67

0.0126

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005816

Spindle pole body

5 of 28

2.29

3.65

4.71e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 371

1.43

2.45

3.42e-10

KW-0067

ATP-binding

6 of 531

1.1

1.04

0.00023

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001245

Serine-threonine/tyrosine-protein kinase, catalytic domain

7 of 13

2.77

7.23

1.14e-14

IPR046349

C1-like domain superfamily

5 of 17

2.51

4.37

3.17e-09

IPR002219

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

5 of 17

2.51

4.37

3.17e-09

IPR017441

Protein kinase, ATP binding site

9 of 187

1.73

3.7

5.71e-12

IPR000719

Protein kinase domain

9 of 256

1.59

3.06

5.98e-11

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00220

Serine/Threonine protein kinases, catalytic domain

9 of 159

1.8

4.22

3.03e-13

SM00033

Calponin homology domain

4 of 17

2.41

3.3

4.08e-07

SM00109

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

3 of 14

2.37

2.28

4.70e-05

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