hupA_3 protein (Jidaibacter acanthamoeba) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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hupA_3

DNA-binding protein HU-alpha; Product derived from UniProtKB/Swiss-Prot:Q9ZF89;Gene name derived from UniProtKB/Swiss-Prot:Q9ZF89; Belongs to the bacterial histone-like protein family. (97 aa)

Predicted Functional Partners:

KIE04278.1

0.489

ihfA_2

0.465

kefB_2

0.410

KIE04280.1

0.407

Your Current Organism:

Jidaibacter acanthamoeba

NCBI taxonomy Id: 86105
Other names: C. Jidaibacter acanthamoeba, Candidatus Jidaibacter acanthamoeba, endosymbiont of Acanthamoeba sp. UWC36

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KIE04278.1	hupA_3	NF27_IN00190	NF27_IN00200	MazG-like protein; Product derived from UniProtKB/Trembl:H8K626.	DNA-binding protein HU-alpha; Product derived from UniProtKB/Swiss-Prot:Q9ZF89;Gene name derived from UniProtKB/Swiss-Prot:Q9ZF89; Belongs to the bacterial histone-like protein family.	0.489
KIE04280.1	hupA_3	NF27_IN00210	NF27_IN00200	Hypothetical protein.	DNA-binding protein HU-alpha; Product derived from UniProtKB/Swiss-Prot:Q9ZF89;Gene name derived from UniProtKB/Swiss-Prot:Q9ZF89; Belongs to the bacterial histone-like protein family.	0.407
hupA_3	KIE04278.1	NF27_IN00200	NF27_IN00190	DNA-binding protein HU-alpha; Product derived from UniProtKB/Swiss-Prot:Q9ZF89;Gene name derived from UniProtKB/Swiss-Prot:Q9ZF89; Belongs to the bacterial histone-like protein family.	MazG-like protein; Product derived from UniProtKB/Trembl:H8K626.	0.489
hupA_3	KIE04280.1	NF27_IN00200	NF27_IN00210	DNA-binding protein HU-alpha; Product derived from UniProtKB/Swiss-Prot:Q9ZF89;Gene name derived from UniProtKB/Swiss-Prot:Q9ZF89; Belongs to the bacterial histone-like protein family.	Hypothetical protein.	0.407
hupA_3	ihfA_2	NF27_IN00200	NF27_HJ00380	DNA-binding protein HU-alpha; Product derived from UniProtKB/Swiss-Prot:Q9ZF89;Gene name derived from UniProtKB/Swiss-Prot:Q9ZF89; Belongs to the bacterial histone-like protein family.	Integration host factor, alpha subunit; Product derived from UniProtKB/Trembl:F7XVY4;Gene name derived from UniProtKB/Trembl:F7XVY4; Belongs to the bacterial histone-like protein family.	0.465
hupA_3	kefB_2	NF27_IN00200	NF27_HQ00040	DNA-binding protein HU-alpha; Product derived from UniProtKB/Swiss-Prot:Q9ZF89;Gene name derived from UniProtKB/Swiss-Prot:Q9ZF89; Belongs to the bacterial histone-like protein family.	Glutathione regulate potassium efflux protein KefB; Product derived from UniProtKB/Trembl:F7XU00;Gene name derived from UniProtKB/Trembl:F7XU00; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.	0.410
ihfA_2	hupA_3	NF27_HJ00380	NF27_IN00200	Integration host factor, alpha subunit; Product derived from UniProtKB/Trembl:F7XVY4;Gene name derived from UniProtKB/Trembl:F7XVY4; Belongs to the bacterial histone-like protein family.	DNA-binding protein HU-alpha; Product derived from UniProtKB/Swiss-Prot:Q9ZF89;Gene name derived from UniProtKB/Swiss-Prot:Q9ZF89; Belongs to the bacterial histone-like protein family.	0.465
ihfA_2	kefB_2	NF27_HJ00380	NF27_HQ00040	Integration host factor, alpha subunit; Product derived from UniProtKB/Trembl:F7XVY4;Gene name derived from UniProtKB/Trembl:F7XVY4; Belongs to the bacterial histone-like protein family.	Glutathione regulate potassium efflux protein KefB; Product derived from UniProtKB/Trembl:F7XU00;Gene name derived from UniProtKB/Trembl:F7XU00; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.	0.410
kefB_2	hupA_3	NF27_HQ00040	NF27_IN00200	Glutathione regulate potassium efflux protein KefB; Product derived from UniProtKB/Trembl:F7XU00;Gene name derived from UniProtKB/Trembl:F7XU00; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.	DNA-binding protein HU-alpha; Product derived from UniProtKB/Swiss-Prot:Q9ZF89;Gene name derived from UniProtKB/Swiss-Prot:Q9ZF89; Belongs to the bacterial histone-like protein family.	0.410
kefB_2	ihfA_2	NF27_HQ00040	NF27_HJ00380	Glutathione regulate potassium efflux protein KefB; Product derived from UniProtKB/Trembl:F7XU00;Gene name derived from UniProtKB/Trembl:F7XU00; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.	Integration host factor, alpha subunit; Product derived from UniProtKB/Trembl:F7XVY4;Gene name derived from UniProtKB/Trembl:F7XVY4; Belongs to the bacterial histone-like protein family.	0.410

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015986

Proton motive force-driven ATP synthesis

10 of 14

2.64

10.07

1.33e-21

GO:1902600

Proton transmembrane transport

10 of 61

2.0

6.02

2.21e-17

GO:0042776

Proton motive force-driven mitochondrial ATP synthesis

2 of 2

2.79

1.7

0.00079

GO:0006119

Oxidative phosphorylation

3 of 35

1.72

1.35

0.0014

GO:0044237

Cellular metabolic process

11 of 2618

0.41

0.34

0.0016

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

8 of 10

2.69

8.22

4.66e-17

GO:0015078

Proton transmembrane transporter activity

11 of 56

2.08

7.05

5.39e-20

GO:0022853

Active ion transmembrane transporter activity

3 of 69

1.43

0.82

0.0165

GO:0015399

Primary active transmembrane transporter activity

3 of 77

1.38

0.76

0.0212

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

2 of 19

1.81

0.73

0.0402

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

10 of 13

2.67

10.53

1.90e-22

GO:0098800

Inner mitochondrial membrane protein complex

11 of 78

1.94

6.09

2.25e-19

GO:0000275

Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

5 of 5

2.79

5.4

6.18e-11

GO:0000276

Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

5 of 8

2.58

4.93

2.73e-10

GO:0000274

Mitochondrial proton-transporting ATP synthase, stator stalk

3 of 3

2.79

3.04

2.47e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8551

Proton-transporting ATP synthase complex, and jmjN domain

10 of 16

2.58

9.9

1.21e-21

CL:8553

Proton-transporting ATP synthase complex

9 of 11

2.7

9.52

6.44e-20

CL:8556

Proton-transporting ATP synthase complex, catalytic core F(1)

6 of 6

2.79

6.4

6.01e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

11 of 102

1.82

5.24

2.51e-18

map01100

Metabolic pathways

11 of 1350

0.7

0.67

1.54e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1852241

Organelle biogenesis and maintenance

8 of 39

2.1

5.31

2.15e-13

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

9 of 66

1.92

4.83

7.64e-14

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

9 of 120

1.66

3.51

4.09e-12

MAP-1430728

Metabolism

9 of 924

0.78

0.68

0.00017

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

9 of 13

2.63

9.04

3.06e-19

GOCC:0005753

Mitochondrial proton-transporting ATP synthase complex

6 of 9

2.61

5.77

5.23e-12

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

5 of 5

2.79

5.17

1.78e-10

GOCC:0000276

Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

4 of 7

2.54

3.66

1.02e-07

GOCC:0098800

Inner mitochondrial membrane protein complex

7 of 63

1.83

3.6

4.52e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0139

CF(1)

3 of 3

2.79

2.63

1.46e-05

KW-0066

ATP synthesis

3 of 3

2.79

2.63

1.46e-05

KW-0375

Hydrogen ion transport

3 of 13

2.15

1.97

0.00014

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02874

ATP synthase alpha/beta family, beta-barrel domain

2 of 4

2.49

0.86

0.0273

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