AIF81897.1 protein (endosymbiont of Acanthamoeba)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

AIF81897.1

LPS-assembly lipoprotein. (170 aa)

Predicted Functional Partners:

AIF81217.1

0.724

AIF81190.1

0.652

AIF81896.1

0.554

AIF81957.1

0.548

AIF80779.1

0.516

AIF81102.1

0.516

AIF81104.1

0.508

AIF81612.1

0.507

AIF81189.1

0.504

AIF81287.1

0.495

Your Current Organism:

endosymbiont of Acanthamoeba

NCBI taxonomy Id: 86106
Other names: e. of Acanthamoeba sp. UWC8, endosymbiont of Acanthamoeba sp. UWC8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIF80779.1	AIF81102.1	I862_01080	I862_02695	COG3164 Predicted membrane protein.	COG0515 Serine/threonine protein kinase.	0.640
AIF80779.1	AIF81104.1	I862_01080	I862_02705	COG3164 Predicted membrane protein.	Hypothetical protein; COG3307 Lipid A core - O-antigen ligase and related enzymes.	0.735
AIF80779.1	AIF81189.1	I862_01080	I862_03140	COG3164 Predicted membrane protein.	Outer membrane protein porin.	0.461
AIF80779.1	AIF81190.1	I862_01080	I862_03145	COG3164 Predicted membrane protein.	COG3203 Outer membrane protein (porin).	0.613
AIF80779.1	AIF81217.1	I862_01080	I862_03285	COG3164 Predicted membrane protein.	Hypothetical protein.	0.741
AIF80779.1	AIF81287.1	I862_01080	I862_03635	COG3164 Predicted membrane protein.	COG1256 Flagellar hook-associated protein.	0.578
AIF80779.1	AIF81612.1	I862_01080	I862_05290	COG3164 Predicted membrane protein.	Flagellar hook-length control protein.	0.760
AIF80779.1	AIF81897.1	I862_01080	I862_06715	COG3164 Predicted membrane protein.	LPS-assembly lipoprotein.	0.516
AIF81102.1	AIF80779.1	I862_02695	I862_01080	COG0515 Serine/threonine protein kinase.	COG3164 Predicted membrane protein.	0.640
AIF81102.1	AIF81104.1	I862_02695	I862_02705	COG0515 Serine/threonine protein kinase.	Hypothetical protein; COG3307 Lipid A core - O-antigen ligase and related enzymes.	0.829
AIF81102.1	AIF81189.1	I862_02695	I862_03140	COG0515 Serine/threonine protein kinase.	Outer membrane protein porin.	0.729
AIF81102.1	AIF81190.1	I862_02695	I862_03145	COG0515 Serine/threonine protein kinase.	COG3203 Outer membrane protein (porin).	0.722
AIF81102.1	AIF81217.1	I862_02695	I862_03285	COG0515 Serine/threonine protein kinase.	Hypothetical protein.	0.761
AIF81102.1	AIF81287.1	I862_02695	I862_03635	COG0515 Serine/threonine protein kinase.	COG1256 Flagellar hook-associated protein.	0.747
AIF81102.1	AIF81612.1	I862_02695	I862_05290	COG0515 Serine/threonine protein kinase.	Flagellar hook-length control protein.	0.764
AIF81102.1	AIF81897.1	I862_02695	I862_06715	COG0515 Serine/threonine protein kinase.	LPS-assembly lipoprotein.	0.516
AIF81102.1	AIF81957.1	I862_02695	I862_07015	COG0515 Serine/threonine protein kinase.	Hypothetical protein.	0.498
AIF81104.1	AIF80779.1	I862_02705	I862_01080	Hypothetical protein; COG3307 Lipid A core - O-antigen ligase and related enzymes.	COG3164 Predicted membrane protein.	0.735
AIF81104.1	AIF81102.1	I862_02705	I862_02695	Hypothetical protein; COG3307 Lipid A core - O-antigen ligase and related enzymes.	COG0515 Serine/threonine protein kinase.	0.829
AIF81104.1	AIF81189.1	I862_02705	I862_03140	Hypothetical protein; COG3307 Lipid A core - O-antigen ligase and related enzymes.	Outer membrane protein porin.	0.651

page 1 of 5

Network Stats

number of nodes:

5

number of edges:

5

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

4

PPI enrichment p-value:

0.375

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000169

Regulation of peptidyl-cysteine S-nitrosylation

2 of 4

3.16

1.37

0.0125

GO:0098974

Postsynaptic actin cytoskeleton organization

2 of 7

2.92

1.31

0.0150

GO:0042730

Fibrinolysis

2 of 9

2.81

1.31

0.0150

GO:0060307

Regulation of ventricular cardiac muscle cell membrane repolarization

2 of 11

2.73

1.3

0.0150

GO:1901385

Regulation of voltage-gated calcium channel activity

2 of 21

2.44

1.12

0.0264

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050998

Nitric-oxide synthase binding

2 of 9

2.81

1.34

0.0134

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0002102

Podosome

2 of 13

2.65

1.35

0.0127

GO:0033017

Sarcoplasmic reticulum membrane

2 of 18

2.51

1.34

0.0127

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32351978

(2020) Erysipelothrix Spp.: Past, Present, and Future Directions in Vaccine Research.

2 of 3

3.29

2.04

0.0015

PMID:38254464

(2024) Pathogenic Potential of Coagulase-Positive Staphylococcus Strains Isolated from Aviary Capercaillies and Free-Living Birds in Southeastern Poland.

2 of 4

3.16

2.03

0.0015

PMID:31078554

(2019) How Environmental Fungi Cause a Range of Clinical Outcomes in Susceptible Hosts.

2 of 9

2.81

1.83

0.0027

PMID:22229971

(2012) Biology and pathogenesis of Acanthamoeba.

2 of 10

2.77

1.83

0.0027

PMID:37889324

(2023) Gallibacterium anatis infection in poultry: a comprehensive review.

2 of 13

2.65

1.77

0.0031

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26252

Mixed, incl. Regulation of peptidyl-cysteine S-nitrosylation, and PKHG1/2/3, pleckstrin homology (PH) domain

3 of 6

3.16

3.77

5.32e-06

CL:19214

Mixed, incl. Fibrinolysis, and Fibrinogen

2 of 12

2.69

1.65

0.0047

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8964041

LDL remodeling

2 of 9

2.81

1.48

0.0085

MAP-8963899

Plasma lipoprotein remodeling

2 of 29

2.3

1.01

0.0360

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

2 of 217

1.43

0.94

0.0195

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005577

Fibrinogen complex

2 of 8

2.86

1.58

0.0062

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0797

Tissue remodeling

2 of 2

3.47

2.7

0.00018

KW-0280

Fibrinolysis

2 of 2

3.47

2.7

0.00018

KW-0420

Kringle

2 of 14

2.62

2.21

0.00071

KW-0720

Serine protease

2 of 43

2.13

1.55

0.0049

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023317

Peptidase S1A, plasmin

2 of 2

3.47

1.8

0.0033

IPR003609

PAN/Apple domain

2 of 4

3.16

1.72

0.0041

IPR038178

Kringle superfamily

2 of 14

2.62

1.23

0.0190

IPR018056

Kringle, conserved site

2 of 13

2.65

1.23

0.0190

IPR000001

Kringle

2 of 14

2.62

1.23

0.0190

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00130

Kringle domain

2 of 14

2.62

1.49

0.0079

SM00462

Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain

2 of 26

2.35

1.33

0.0123

SM00020

Trypsin-like serine protease

2 of 63

1.97

0.91

0.0451

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