STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
askAspartate kinase; Catalyzes the phosphorylation of aspartate. The product of this reaction can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine; Belongs to the aspartokinase family. (428 aa)    
Predicted Functional Partners:
thrA
Homoserine dehydrogenase; Catalyzes NAD-dependent reduction of aspartate 4-semialdehyde into homoserine. This reaction is the third step in a pathway leading from aspartate to homoserine. The latter participates in the biosynthesis of threonine and then isoleucine as well as in that of methionine.
 
 0.998
asd
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADP-dependent reductive dephosphorylation of L-aspartyl phosphate to L-aspartate-semialdehyde. Second step in the common biosynthetic pathway leading from aspartate to diaminopimelate and lysine, to methionine, and to threonine.
 
 
 0.998
lysA
Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
   
 0.912
dapB
Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family.
 
  
 0.895
argG
Argininosuccinate synthase; Catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate; Belongs to the argininosuccinate synthase family. Type 2 subfamily.
  
 
 0.858
aspC
Aspartate transaminase; Catalyses the following reaction: L-aspartate + 2-oxoglutarate <=> oxaloacetate + L-glutamate.
  
 0.854
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
  0.833
nadB
L-aspartate oxidase; Quinolinate synthetase B subunit. Quinolinate synthetase complex (A and B subunits) is involved in the de novo biosynthetic pathway of pyridine nucleotide formation. It catalyses the formation of quinolinic acid.
    
 0.814
pyrB
Catalyzes the conversion of aspartate and carbamoyl phosphate to carbamoylaspartate, the second step in the de novo biosynthesis of pyrimidine; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
    
 0.807
aspA
Aspartate ammonia-lyase; Catalyzes the reversible conversion of aspartate to fumarate and ammonia.
     
 0.807
Your Current Organism:
Glutamicibacter arilaitensis
NCBI taxonomy Id: 861360
Other names: Arthrobacter arilaitensis CIP 108037, Arthrobacter arilaitensis Re117, G. arilaitensis Re117, Glutamicibacter arilaitensis Re117
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