node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AARI_02880 | umuD | AARI_02880 | AARI_03500 | AraC-family transcriptional regulator; Identified by match to protein domain PF00165: bacterial regulatory helix-turn-helix proteins, AraC family. | Putative DNA polymerase subunit UmuD; In Escherichia coli umuD and umuC genes have been shown to encode E. coli s fifth DNA polymerase, pol V (consisting of a heterotrimer of UmuD (2)C). The main function of pol V appears to be the bypass of DNA lesions that would otherwise block replication by pols I-IV; Belongs to the peptidase S24 family. | 0.446 |
AARI_03520 | umuC | AARI_03520 | AARI_03510 | Glycosyl hydrolase, family 3; Identified by match to PF00933. Glycoside hydrolase family 3 comprises enzymes with a number of known activities; beta-glucosidase (EC:3.2.1.21); beta-xylosidase (EC:3.2.1.37); N-acetyl beta-glucosaminidase (EC:3.2.1.52); glucan beta-1,3-glucosidase (EC:3.2.1.58); cellodextrinase (EC:3.2.1.74); exo-1,3-1,4-glucanase (EC:3. 2.1). | Putative DNA polymerase subunit UmuC; In Escherichia coli umuD and umuC genes have been shown to encode E. coli s fifth DNA polymerase, pol V (consisting of a heterotrimer of UmuD (2)C). The main function of pol V appears to be the bypass of DNA lesions that would otherwise block replication by pols I-IV. | 0.566 |
AARI_03520 | umuD | AARI_03520 | AARI_03500 | Glycosyl hydrolase, family 3; Identified by match to PF00933. Glycoside hydrolase family 3 comprises enzymes with a number of known activities; beta-glucosidase (EC:3.2.1.21); beta-xylosidase (EC:3.2.1.37); N-acetyl beta-glucosaminidase (EC:3.2.1.52); glucan beta-1,3-glucosidase (EC:3.2.1.58); cellodextrinase (EC:3.2.1.74); exo-1,3-1,4-glucanase (EC:3. 2.1). | Putative DNA polymerase subunit UmuD; In Escherichia coli umuD and umuC genes have been shown to encode E. coli s fifth DNA polymerase, pol V (consisting of a heterotrimer of UmuD (2)C). The main function of pol V appears to be the bypass of DNA lesions that would otherwise block replication by pols I-IV; Belongs to the peptidase S24 family. | 0.580 |
dinB | recA | AARI_20850 | AARI_11010 | Putative DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | RecA bacterial DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.850 |
dinB | umuD | AARI_20850 | AARI_03500 | Putative DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Putative DNA polymerase subunit UmuD; In Escherichia coli umuD and umuC genes have been shown to encode E. coli s fifth DNA polymerase, pol V (consisting of a heterotrimer of UmuD (2)C). The main function of pol V appears to be the bypass of DNA lesions that would otherwise block replication by pols I-IV; Belongs to the peptidase S24 family. | 0.828 |
ftsX | tctB | AARI_12190 | AARI_10450 | Cell division membrane protein FtsX; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. | Putative citrate transport protein TctB; Possible TctB component of the TctCBA citrate uptake system (TC 2.A.1.1). | 0.769 |
ftsX | umuD | AARI_12190 | AARI_03500 | Cell division membrane protein FtsX; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. | Putative DNA polymerase subunit UmuD; In Escherichia coli umuD and umuC genes have been shown to encode E. coli s fifth DNA polymerase, pol V (consisting of a heterotrimer of UmuD (2)C). The main function of pol V appears to be the bypass of DNA lesions that would otherwise block replication by pols I-IV; Belongs to the peptidase S24 family. | 0.769 |
recA | dinB | AARI_11010 | AARI_20850 | RecA bacterial DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Putative DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.850 |
recA | recN | AARI_11010 | AARI_11620 | RecA bacterial DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.877 |
recA | ruvA | AARI_11010 | AARI_17470 | RecA bacterial DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.809 |
recA | umuC | AARI_11010 | AARI_03510 | RecA bacterial DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Putative DNA polymerase subunit UmuC; In Escherichia coli umuD and umuC genes have been shown to encode E. coli s fifth DNA polymerase, pol V (consisting of a heterotrimer of UmuD (2)C). The main function of pol V appears to be the bypass of DNA lesions that would otherwise block replication by pols I-IV. | 0.850 |
recA | umuD | AARI_11010 | AARI_03500 | RecA bacterial DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Putative DNA polymerase subunit UmuD; In Escherichia coli umuD and umuC genes have been shown to encode E. coli s fifth DNA polymerase, pol V (consisting of a heterotrimer of UmuD (2)C). The main function of pol V appears to be the bypass of DNA lesions that would otherwise block replication by pols I-IV; Belongs to the peptidase S24 family. | 0.931 |
recA | uvrC | AARI_11010 | AARI_19080 | RecA bacterial DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.515 |
recN | recA | AARI_11620 | AARI_11010 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | RecA bacterial DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.877 |
recN | ruvA | AARI_11620 | AARI_17470 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.780 |
recN | umuD | AARI_11620 | AARI_03500 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Putative DNA polymerase subunit UmuD; In Escherichia coli umuD and umuC genes have been shown to encode E. coli s fifth DNA polymerase, pol V (consisting of a heterotrimer of UmuD (2)C). The main function of pol V appears to be the bypass of DNA lesions that would otherwise block replication by pols I-IV; Belongs to the peptidase S24 family. | 0.624 |
recN | uvrC | AARI_11620 | AARI_19080 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.574 |
ruvA | recA | AARI_17470 | AARI_11010 | Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | RecA bacterial DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.809 |
ruvA | recN | AARI_17470 | AARI_11620 | Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.780 |
ruvA | umuD | AARI_17470 | AARI_03500 | Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | Putative DNA polymerase subunit UmuD; In Escherichia coli umuD and umuC genes have been shown to encode E. coli s fifth DNA polymerase, pol V (consisting of a heterotrimer of UmuD (2)C). The main function of pol V appears to be the bypass of DNA lesions that would otherwise block replication by pols I-IV; Belongs to the peptidase S24 family. | 0.437 |