STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
AARI_04010AraC-family transcriptional regulator; Identified by match to protein domain PF00165: bacterial regulatory helix-turn-helix proteins, AraC family. (529 aa)    
Predicted Functional Partners:
Putative siderophore-interacting protein; Identified by match to protein family PF04954. Match to protein domain PF08021. Possibly involved in removal of iron from iron-siderophore complexes.
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Lysine export transcriptional regulatory protein LysG; Probable transcriptional regulator of lysE. Identified by similarity to protein SP: P94632 (Corynebacterium glutamicum); Belongs to the LysR transcriptional regulatory family.
GntR-family transcriptional regulator; Identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships.
Putative NAD-dependent deacetylase; Identified by match to PF02146: Sir2 family. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. Function: modulate the activities of several enzymes which are inactive in their acetylated form. Catalytic activity: NAD+ + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.
AraC-family transcriptional regulator; Identified by match to protein domain PF00165: bacterial regulatory helix-turn-helix proteins, AraC family.
Iron-siderophore ABC transporter, substrate-binding protein; TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, binding protein (BP), ISVH-family (iron siderophores, vitamin B12 and hemin).
Your Current Organism:
Glutamicibacter arilaitensis
NCBI taxonomy Id: 861360
Other names: Arthrobacter arilaitensis CIP 108037, Arthrobacter arilaitensis Re117, G. arilaitensis Re117, Glutamicibacter arilaitensis Re117
Server load: low (20%) [HD]