STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
sdhCThe succinate dehydrogenase complex catalyses the interconversion of fumarate and succinate. It contains several subunits: a flavoprotein (SdhA), an iron-sulfur protein (SdhB), and membrane anchor proteins (SdhC and SdhD). Involved in the TCA cycle. (126 aa)    
Predicted Functional Partners:
sdhB
The succinate dehydrogenase complex catalyses the interconversion of fumarate and succinate. It contains several subunits: a flavoprotein (SdhA), an iron-sulfur protein (SdhB), and membrane anchor proteins (SdhC and SdhD). Involved in the TCA cycle.
 
 0.999
sdhA
The succinate dehydrogenase complex catalyses the interconversion of fumarate and succinate. It contains several subunits: a flavoprotein (SdhA), an iron-sulfur protein (SdhB), and membrane anchor proteins (SdhC and SdhD). Involved in the TCA cycle.
 
 0.999
sdhD
The succinate dehydrogenase complex catalyses the interconversion of fumarate and succinate. It contains several subunits: a flavoprotein (SdhA), an iron-sulfur protein (SdhB), and membrane anchor proteins (SdhC and SdhD). Involved in the TCA cycle.
 
 0.999
sdhA-2
Putative succinate dehydrogenase flavoprotein subunit; The succinate dehydrogenase complex catalyses the interconversion of fumarate and succinate. It contains several subunits: a flavoprotein (SdhA), an iron-sulfur protein (SdhB), and membrane anchor proteins (SdhC and SdhD). Involved in the TCA cycle.
 
 0.998
AARI_25590
Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.980
sucC
succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.975
sucD
succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.973
sucA
It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61 (Dihydrolipoyllysine-residue succinyltransferase), which also binds multiple copies of EC 1.8.1.4 (Dihydrolipoyl dehydrogenase). Involved in the TCA cycle.
  
  
 0.966
fumC
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
 0.953
cat1
Putative succinyl-CoA:coenzyme A transferase; Identified by similarity to protein SP:P38946 (Clostridium kluyveri). Succinyl-CoA:coenzyme A transferase forms succinyl-CoA from succinate and acetyl- CoA and is believed to be involved in anaerobic succinate degradation.
   
 
 0.909
Your Current Organism:
Glutamicibacter arilaitensis
NCBI taxonomy Id: 861360
Other names: Arthrobacter arilaitensis CIP 108037, Arthrobacter arilaitensis Re117, G. arilaitensis Re117, Glutamicibacter arilaitensis Re117
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