STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lpdAE3 component of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes. (469 aa)    
Predicted Functional Partners:
sucA
It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61 (Dihydrolipoyllysine-residue succinyltransferase), which also binds multiple copies of EC 1.8.1.4 (Dihydrolipoyl dehydrogenase). Involved in the TCA cycle.
  
 0.999
sucB
Dihydrolipoyllysine-residue succinyltransferase; It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex, which is involved in the TCA cycle.
 0.978
AARI_09810
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
 0.976
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
  
 0.954
AARI_10530
Also named branched-chain alpha-keto acid dehydrogenase E1 component beta chain. The branched-chain alpha-keto dehydrogenase complex catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2; EC 2.3. 1.168) and lipoamide dehydrogenase (E3; EC1.8.1.4). The E1 component is composed of alpha an [...]
 0.933
AARI_28690
Possible component of pyruvate dehydrogenase (EC 2. 3.1.12), branched-chain alpha-ketoacid dehydrogenase (EC 2. 3.1.168) or 2-oxoglutarate dehydrogenase (EC 2.3.1.61) complexes.
 0.919
AARI_10540
Possible lipoamide acyltransferase or N-terminal section of lipoamide acyltransferase (lipoyl-binding site). The branched-chain alpha-keto dehydrogenase complex catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2; EC 2.3.1.168) and lipoamide dehydrogenase (E3; EC1.8.1.4). The E1 compon [...]
  
 0.913
AARI_24250
Possible component of pyruvate dehydrogenase (EC 2. 3.1.12), branched-chain alpha-ketoacid dehydrogenase (EC 2. 3.1.168) or 2-oxoglutarate dehydrogenase (EC 2.3.1.61) complexes.
 0.909
AARI_09800
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
 0.880
AARI_24260
Possible component of pyruvate dehydrogenase (EC 2. 3.1.12), branched-chain alpha-ketoacid dehydrogenase (EC 2. 3.1.168) or 2-oxoglutarate dehydrogenase (EC 2.3.1.61) complexes.
 0.875
Your Current Organism:
Glutamicibacter arilaitensis
NCBI taxonomy Id: 861360
Other names: Arthrobacter arilaitensis CIP 108037, Arthrobacter arilaitensis Re117, G. arilaitensis Re117, Glutamicibacter arilaitensis Re117
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